YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|7494218
Organism:	Plasmodium falciparum
Length:	1367 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|7494218.

Description	E-value	Query Range	Subject Range
gi\|207090325 - gi\|207090325\|gb\|EDZ67596.1\| isoleucyl-tRNA synthetase [Nitrosococcus oceani AFC27] gi\|254433992, gi... - gi\|254433992\|ref\|ZP_05047500.1\| isoleucyl-tRNA synthetase [Nitrosococcus oceani AFC27], gi\|224410671... SYI_NITOC - Isoleucine--tRNA ligase OS=Nitrosococcus oceani (strain ATCC 19707 / NCIMB 11848) GN=ileS PE=3 SV=1	634.0	[0..204]	[1367..3]
SYI_GLOVI - Isoleucyl-tRNA synthetase OS=Gloeobacter violaceus GN=ileS PE=3 SV=1 SYI_GLOVI - Isoleucine--tRNA ligase OS=Gloeobacter violaceus (strain PCC 7421) GN=ileS PE=3 SV=1	629.0	[0..201]	[1367..4]
gi\|82703767, gi\|... - gi\|82703767\|ref\|YP_413333.1\| isoleucyl-tRNA synthetase [Nitrosospira multiformis ATCC 25196], gi\|824...	624.0	[0..204]	[1367..3]
gi\|90438201, gi\|... - gi\|90580543\|ref\|ZP_01236348.1\| isoleucyl-tRNA synthetase [Vibrio angustum S14], gi\|90438201\|gb\|EAS63...	621.0	[0..204]	[1367..3]
gi\|89051658, gi\|... - gi\|89072554\|ref\|ZP_01159126.1\| isoleucyl-tRNA synthetase [Photobacterium sp. SKA34], gi\|89051658\|gb\|...	617.0	[0..204]	[1367..3]
gi\|90326503, gi\|... - gi\|90412466\|ref\|ZP_01220469.1\| isoleucyl-tRNA synthetase [Photobacterium profundum 3TCK], gi\|9032650...	616.0	[0..204]	[1367..3]
SYI_PHOPR - Isoleucine--tRNA ligase OS=Photobacterium profundum GN=ileS PE=3 SV=1 SYI_PHOPR - Isoleucine--tRNA ligase OS=Photobacterium profundum (strain SS9) GN=ileS PE=3 SV=1	614.0	[0..204]	[1367..3]
SYI_BURTA - Isoleucine--tRNA ligase OS=Burkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 1... gi\|167618175 - gi\|167618175\|ref\|ZP_02386806.1\| isoleucyl-tRNA synthetase [Burkholderia thailandensis Bt4]	609.0	[0..192]	[1367..1]
gi\|86161718, gi\|... - gi\|87123001\|ref\|ZP_01078860.1\| isoleucyl-tRNA synthetase [Marinomonas sp. MED121], gi\|86161718\|gb\|EA...	608.0	[0..204]	[1367..3]
gi\|67667139, gi\|... - gi\|67667139\|ref\|ZP_00464370.1\| Isoleucyl-tRNA synthetase, class Ia [Burkholderia cenocepacia HI2424]... gi\|67093110, gi\|... - gi\|67659234\|ref\|ZP_00456598.1\| Isoleucyl-tRNA synthetase, class Ia [Burkholderia cenocepacia AU 1054...	606.0	[0..190]	[1367..63]

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Predicted Domain #1

Region A:
Residues: [1-224]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTILLTLFII YVCLIGHLTK VYIKENISNQ KKNPLNFIRR KHNNTKKNRK LSFNINKNIN  60
   61 HCKRIVKVEP FFIHKNVRRY VYRRSCFIFN IWNSSKVIKD IYKYIDSCTS FLRKFKSLPS 120
  121 IINVENKKYG KLEKRKKEKN DLCPNIFITY SSNNVPRNIS NKLEHFIYKQ KDIPKEQNIL 180
  181 TYDFFKRDEE LLNDQNRNDF IKKYYNPSYH CDEHPFEHIY NIKD

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [225-326]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEHIYDKSII NYIYDLKRKE EIEYIRKFNR SHYLNSYLLI YPPPNLSGNL HAGHFFNFIH  60
   61 QHIFFLYNKY IMGKYAIPFF GFDHGGLSAH EMFAKHMRGE EL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	113.0
Match:	2v0cA
Description:	No description for 2v0cA was found.

Predicted Domain #3

Region A:
Residues: [327-1367]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GREKYINEIK KWQENLKENM LKDLQNMNIT YNEKMLFNTM DKGMIDLINK AFYILYKNNM  60
   61 IINRLYPVYY CKELKTAIPK MDIQFKNAEN KDIYNLKCYL VKNKNKIDNI YDDKKCIATK 120
  121 NENDHNMNNN DITYCSNNPP KNVTNKNDDT YEKINFFEKN NMSSNCICGD FTITNNDDKY 180
  181 EEKKKKIKNM IEEYDCKEIK FFEKKKFPYY YLNEEELKNK ALINVSKYIY INIENIEDIN 240
  241 NIVAILYYSS NKKKYENMYA LLPHSNVIIP LIFHKKKNFP SLISGNKKGE EREEIKDSKE 300
  301 IKEREEIKER EEIKDSKESK ERDDNNNNID DDDDDIFLPV YSLEKKHDYS FNINKEKGTS 360
  361 QLFFNVSHGK KEHMTYNINN DEKEKENNLI NIINCRKKDK ELKFAYYKNY KCTLILSEHL 420
  421 CIKYDELCNM YYNNSGNKNF NILPCNRKNY FLENYETHPK DWILNRQIWY GHTIPLFKYE 480
  481 HFVTKEESKE GYEDIEKKNK IINKNNNNDK NNNNNNDKNN NNNDKNNNNN DNNKNIIIAD 540
  541 HFNCFVYGKN VDEAYENLIK SNLFKKECIK KEYLKNDDIL DSWFSSCLYF LHCLNSNNID 600
  601 IYDLLKKKKS LVDFTCTGQD ILYPWILRSF ILLNYFIEND YLNELLPSKD NYDIVHILQG 660
  661 LKKEKDNKYL STSILSKTVK FHGILKDDVG KKISKSDENS TYYKKYLEDI NMDTLRLSFT 720
  721 FLQKNVEDIV WSKNNIYKSE KFIKKFWNVG QFIKQNCNYE SYIRMSKVIL ANTNNINIEN 780
  781 IDDDSIDGDC IDDNIKVLEF LKTKTQHISC ISIFEAYYYT IHLILQYMKL YNLNKSIILI 840
  841 NDFIMNYFSK FFLNYYSSGK SQISNFLIYY IFKGLIKFLY PFIPHICEIL YIQIFFKEKE 900
  901 KKQILNASSP PMLLYENYKF FPNQKFSLEP KIQSVVSDHF LTFMEIYNFL RKFKKENKET 960
  961 ICNNNTLYLY IKQKKGAELT LLYFKNEEHM LKRAFHMNII FNACEKNKLG YSFLNEKEHI1020
 1021 QRLNTRKVIY DCDRFVVLAQ V

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	144.0
Match:	1ffyA
Description:	Isoleucyl-tRNA synthetase (IleRS)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.84668360172717	bayes_pls_golite062009
ligase activity	0.41353894226697	bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds	0.1911539125531	bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds	0.1911539125531	bayes_pls_golite062009
aminoacyl-tRNA ligase activity	0.178548924377401	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: