YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|225854898, gi...
Organism:	Streptococcus pneumoniae JJA
Length:	242 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|225854898, gi....

Description	E-value	Query Range	Subject Range
gi\|25316730 - pir\|\|F98035 tRNA (guanosine-2'-O-)-methyltransferase (EC 2.1.1.34) [imported] - Streptococcus pneumo... gi\|15903354, gi\|... - gi\|15903354\|ref\|NP_358904.1\| tRNA (guanosine-2'-O-)-methyltransferase [Streptococcus pneumoniae R6],...	266.0	[0..1]	[242..12]
gi\|116077391, gi... - gi\|116516815\|ref\|YP_816752.1\| TrmH family RNA methyltransferase group 3 [Streptococcus pneumoniae D3... gi\|147928676, gi... - gi\|148992659\|ref\|ZP_01822327.1\| pyridoxine biosynthesis protein [Streptococcus pneumoniae SP9-BS68],... gi\|168483931, gi... - gi\|172042719\|gb\|EDT50765.1\| RNA methyltransferase, TrmH family, group 3 [Streptococcus pneumoniae CD... gi\|147756539, gi... - gi\|148997484\|ref\|ZP_01825089.1\| pyridoxine biosynthesis protein [Streptococcus pneumoniae SP11-BS70]... gi\|183571884, gi... - gi\|183571884\|gb\|EDT92412.1\| RNA methyltransferase, TrmH family, group 3 [Streptococcus pneumoniae SP... gi\|168575914, gi... - gi\|183578281\|gb\|EDT98809.1\| RNA methyltransferase, TrmH family, group 3 [Streptococcus pneumoniae ML... gi\|168996353, gi... - gi\|169833851\|ref\|YP_001694873.1\| RNA methyltransferase [Streptococcus pneumoniae Hungary19A-6], gi\|1...	265.0	[0..1]	[242..1]
gi\|94548650, gi\|... - gi\|94995142\|ref\|YP_603240.1\| 23S rRNA Gm2251 methyltransferase [Streptococcus pyogenes MGAS10750], g... gi\|71904302, gi\|... - gi\|71904302\|ref\|YP_281105.1\| 23S rRNA methyltransferase [Streptococcus pyogenes MGAS6180], gi\|718033... gi\|94991229, gi\|... - gi\|94991229\|ref\|YP_599329.1\| 23S rRNA Gm2251 methyltransferase [Streptococcus pyogenes MGAS10270], g...	261.0	[0..1]	[241..16]
gi\|94542791, gi\|... - gi\|94989283\|ref\|YP_597384.1\| 23S rRNA Gm2251 methyltransferase [Streptococcus pyogenes MGAS9429], gi... gi\|94993172, gi\|... - gi\|94993172\|ref\|YP_601271.1\| 23S rRNA Gm2251 methyltransferase [Streptococcus pyogenes MGAS2096], gi...	261.0	[0..1]	[241..16]
gi\|77413808, gi\|... - gi\|77413808\|ref\|ZP_00789988.1\| RNA methyltransferase, TrmH family, group 3 [Streptococcus agalactiae... gi\|77171728, gi\|... - gi\|77409659\|ref\|ZP_00786329.1\| RNA methyltransferase, TrmH family, group 3 [Streptococcus agalactiae...	261.0	[0..2]	[242..11]
gi\|23094631, gi\|... - gi\|25010279\|ref\|NP_734674.1\| hypothetical protein gbs0204 [Streptococcus agalactiae NEM316], gi\|2309...	260.0	[0..2]	[242..9]
gi\|19749091, gi\|... - gi\|19749091\|gb\|AAL98486.1\| putative tRNA/rRNA methyltransferase [Streptococcus pyogenes MGAS8232], g... gi\|13622961, gi\|... - gi\|15675741\|ref\|NP_269915.1\| putative tRNA/rRNA methyltransferase [Streptococcus pyogenes M1 GAS], g... gi\|71911465, gi\|... - gi\|71911465\|ref\|YP_283015.1\| 23S rRNA methyltransferase [Streptococcus pyogenes MGAS5005], gi\|718542... gi\|139474428, gi... - gi\|139474428\|ref\|YP_001129144.1\| SpoU rRNA methylase family protein [Streptococcus pyogenes str. Man...	260.0	[0..1]	[241..7]
gi\|56807805 - gi\|56807805\|ref\|ZP_00365654.1\| COG0566: rRNA methylases [Streptococcus pyogenes M49 591] gi\|209541283, gi... - gi\|209560082\|ref\|YP_002286554.1\| 23S rRNA methyltransferase [Streptococcus pyogenes NZ131], gi\|20954...	260.0	[0..1]	[241..7]
gi\|50904080, gi\|... - gi\|50915006\|ref\|YP_060978.1\| 23S rRNA Gm2251 methyltransferase [Streptococcus pyogenes MGAS10394], g...	260.0	[0..1]	[241..16]
gi\|76787268, gi\|... - gi\|76787268\|ref\|YP_328940.1\| RNA methyltransferase [Streptococcus agalactiae A909], gi\|76562325\|gb\|A... gi\|77176031, gi\|... - gi\|77405353\|ref\|ZP_00782448.1\| RNA methyltransferase, TrmH family, group 3 [Streptococcus agalactiae... gi\|77410962, gi\|... - gi\|77410962\|ref\|ZP_00787318.1\| RNA methyltransferase, TrmH family, group 3 [Streptococcus agalactiae... gi\|76799582, gi\|... - gi\|76799582\|ref\|ZP_00781707.1\| RNA methyltransferase, TrmH family, group 3 [Streptococcus agalactiae... gi\|22533220, gi\|... - gi\|22536393\|ref\|NP_687244.1\| RNA methyltransferase [Streptococcus agalactiae 2603V/R], gi\|22533220\|g...	260.0	[0..2]	[242..11]

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Predicted Domain #1

Region A:
Residues: [1-242]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKTNDIVYGV HAVTEALLAN TGNKLYLQED LRGKNVEKVK ELATEKKVSI SWTSKKSLSE  60
   61 ITEGAVHQGF VLRVSEFAYS ELDYILAKTR QEENPLLLIL DGLTDPHNLG SILRTADATN 120
  121 VSGVIIPKHR TVGVTPVVAK TATGAIEHVP IARVTNLSQT LDKLKDEGFW TFGTDMNGTP 180
  181 CHKWNTKGKI ALIIGNEGKG ISSNIKKQVD EMITIPMNGH VQSLNASVAA AILMYEVFRN 240
  241 RL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	62.30103
Match:	1gz0A
Description:	RlmB, C-terminal domain; RlmB, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
RNA methyltransferase activity	4.23455016472464	bayes_pls_golite062009
methyltransferase activity	3.59960278169345	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	3.51722801996622	bayes_pls_golite062009
rRNA methyltransferase activity	3.14976989427746	bayes_pls_golite062009
tRNA methyltransferase activity	2.33123191403389	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	2.23755555119187	bayes_pls_golite062009
tRNA (guanine) methyltransferase activity	2.14623472760939	bayes_pls_golite062009
transferase activity	1.63934797352054	bayes_pls_golite062009
structural constituent of ribosome	1.0137045454994	bayes_pls_golite062009
catalytic activity	0.797300463760338	bayes_pls_golite062009
N-methyltransferase activity	0.736216022000293	bayes_pls_golite062009
structural molecule activity	0.694233763389628	bayes_pls_golite062009
binding	0.650146274744039	bayes_pls_golite062009
nucleic acid binding	0.404179021204849	bayes_pls_golite062009
rRNA (guanine) methyltransferase activity	0.319046095835882	bayes_pls_golite062009
	0.16936231012632	bayes_pls_golite062009
snoRNA binding	0.155192244522672	bayes_pls_golite062009
protein binding	0.031057919963412	bayes_pls_golite062009
rRNA (guanine-N1-)-methyltransferase activity	6.26422903788337E-4	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: