YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|254815934
Organism:	Mycobacterium tuberculosis KZN 4207
Length:	280 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|254815934.

Description	E-value	Query Range	Subject Range
gi\|71915941, gi\|... - gi\|72162209\|ref\|YP_289866.1\| tRNA (adenine-58-N(1)-) methyltransferase [Thermobifida fusca YX], gi\|7... gi\|48837251 - ref\|ZP_00294246.1\| COG2519: tRNA(1-methyladenosine) methyltransferase and related methyltransferases...	213.0	[0..3]	[280..7]
gi\|29610338, gi\|... - gi\|29833216\|ref\|NP_827850.1\| hypothetical protein SAV_6674 [Streptomyces avermitilis MA-4680], gi\|29...	206.0	[0..3]	[280..10]
gi\|41407940, gi\|... - gi\|41407940\|ref\|NP_960776.1\| hypothetical protein MAP1842c [Mycobacterium avium subsp. paratuberculo...	206.0	[0..1]	[280..1]
gi\|21220147, gi\|... - gi\|6119693\|emb\|CAB59504.1\| conserved hypothetical protein SCI41.34c [Streptomyces coelicolor A3(2)],...	206.0	[0..3]	[280..10]
gi\|221230158, gi... - gi\|221230158\|ref\|YP_002503574.1\| hypothetical protein MLBr_01313 [Mycobacterium leprae Br4923], gi\|2... gi\|15827681 - gi\|15827681\|ref\|NP_301944.1\| hypothetical protein ML1313 [Mycobacterium leprae TN] gi\|25398117, gi\|... - gi\|4200266\|emb\|CAA22923.1\| hypothetical protein MLCB2533.09 [Mycobacterium leprae], pir\|\|C87073 cons...	198.0	[0..1]	[275..1]
gi\|90206141, gi\|... - gi\|90206141\|ref\|ZP_01208777.1\| tRNA (adenine-N(1)-)-methyltransferase [Mycobacterium vanbaalenii PYR...	196.0	[0..1]	[275..1]
gi\|3790599 - gi\|3790599\|gb\|AAC68688.1\| unknown [Rhodococcus erythropolis]	196.0	[0..4]	[277..43]
gi\|111222285, gi... - gi\|111222285\|ref\|YP_713079.1\| SAM-dependent methyltransferase involved in tRNA-Met maturation [Frank...	196.0	[0..3]	[280..16]
gi\|466999, gi\|21... - gi\|466999\|gb\|AAA17184.1\| pimT; B2126_C1_165 [Mycobacterium leprae], pir\|\|S72844 beta-aspartate methy...	195.0	[0..1]	[273..1]
gi\|108770521, gi... - gi\|108800102\|ref\|YP_640299.1\| tRNA (adenine-N(1)-)-methyltransferase [Mycobacterium sp. MCS], gi\|108... gi\|119869230, gi... - gi\|92916456\|ref\|ZP_01285075.1\| tRNA (adenine-N(1)-)-methyltransferase [Mycobacterium sp. KMS], gi\|92... gi\|126435727, gi... - gi\|92907942\|ref\|ZP_01276721.1\| tRNA (adenine-N(1)-)-methyltransferase [Mycobacterium sp. JLS], gi\|92...	195.0	[0..1]	[276..1]

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Predicted Domain #1

Region A:
Residues: [1-280]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSATGPFSIG ERVQLTDAKG RRYTMSLTPG AEFHTHRGSI AHDAVIGLEQ GSVVKSSNGA  60
   61 LFLVLRPLLV DYVMSMPRGP QVIYPKDAAQ IVHEGDIFPG ARVLEAGAGS GALTLSLLRA 120
  121 VGPAGQVISY EQRADHAEHA RRNVSGCYGQ PPDNWRLVVS DLADSELPDG SVDRAVLDML 180
  181 APWEVLDAVS RLLVAGGVLM VYVATVTQLS RIVEALRAKQ CWTEPRAWET LQRGWNVVGL 240
  241 AVRPQHSMRG HTAFLVATRR LAPGAVAPAP LGRKREGRDG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	54.154902
Match:	1i9gA
Description:	Probable methyltransferase Rv2118c
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
methyltransferase activity	4.15445027778357	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	4.07153733729662	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	3.39429041855776	bayes_pls_golite062009
RNA methyltransferase activity	3.07428840534971	bayes_pls_golite062009
N-methyltransferase activity	3.0539218951403	bayes_pls_golite062009
protein methyltransferase activity	3.01384869242051	bayes_pls_golite062009
rRNA methyltransferase activity	2.29640050660273	bayes_pls_golite062009
transferase activity	2.22303238506686	bayes_pls_golite062009
tRNA methyltransferase activity	1.95598912777096	bayes_pls_golite062009
histone methyltransferase activity	1.90505369820945	bayes_pls_golite062009
DNA-methyltransferase activity	1.63765148226572	bayes_pls_golite062009
arginine N-methyltransferase activity	1.6030970825293	bayes_pls_golite062009
protein-arginine N-methyltransferase activity	1.6030970825293	bayes_pls_golite062009
catalytic activity	1.25333584501255	bayes_pls_golite062009
histone-arginine N-methyltransferase activity	1.05897361334523	bayes_pls_golite062009
tRNA (cytosine)-methyltransferase activity	0.966788807255255	bayes_pls_golite062009
tRNA (cytosine-5-)-methyltransferase activity	0.966788807255255	bayes_pls_golite062009
tRNA (adenine)-methyltransferase activity	0.778520793236291	bayes_pls_golite062009
tRNA (adenine-N1-)-methyltransferase activity	0.778520793236291	bayes_pls_golite062009
site-specific DNA-methyltransferase (adenine-specific) activity	0.703178429468566	bayes_pls_golite062009
protein-arginine omega-N monomethyltransferase activity	0.639377525568296	bayes_pls_golite062009
rRNA (adenine) methyltransferase activity	0.533090627724779	bayes_pls_golite062009
rRNA (adenine-N6,N6-)-dimethyltransferase activity	0.455449410561251	bayes_pls_golite062009
tRNA (guanine) methyltransferase activity	0.203168546434167	bayes_pls_golite062009
protein-arginine omega-N asymmetric methyltransferase activity	0.130104080746388	bayes_pls_golite062009
histone methyltransferase activity (H4-R3 specific)	0.130042730841119	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: