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View Structure Prediction Details

Protein: MAN1B1
Organism: Homo sapiens
Length: 699 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MAN1B1.

Description E-value Query
Range
Subject
Range
gi|109109679 - gi|109109679|ref|XP_001091256.1| PREDICTED: alpha 1,2-mannosidase isoform 2 [Macaca mulatta]
0.0 [1..699] [1..699]
MAN1B1 - mannosidase, alpha, class 1B, member 1
gi|123996749, gi... - gi|123996749|gb|ABM85976.1| mannosidase, alpha, class 1B, member 1 [synthetic construct], gi|1239819...
0.0 [1..699] [1..699]
gi|114627662 - gi|114627662|ref|XP_001135997.1| PREDICTED: alpha 1,2-mannosidase isoform 8 [Pan troglodytes]
0.0 [1..699] [1..699]
MA1B1_MOUSE - Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase OS=Mus musculus GN=Man1b1 PE=1 ...
0.0 [46..699] [12..658]
MA1B1_RAT - Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase OS=Rattus norvegicus GN=Man1b1 ...
0.0 [46..699] [11..657]
gi|73967467 - gi|73967467|ref|XP_537786.2| PREDICTED: similar to Endoplasmic reticulum mannosyl-oligosaccharide 1,...
0.0 [46..698] [11..656]

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Predicted Domain #1
Region A:
Residues: [1-162]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAACEGRRSG ALGSSQSDFL TPPVGGAPWA VATTVVMYPP PPPPPHRDFI SVTLSFGENY  60
   61 DNSKSWRRRS CWRKWKQLSR LQRNMILFLL AFLLFCGLLF YINLADHWKA LAFRLEEEQK 120
  121 MRPEIAGLKP ANPPVLPAPQ KADTDPENLP EISSQKTQRH IQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [163-699]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RGPPHLQIRP PSQDLKDGTQ EEATKRQEAP VDPRPEGDPQ RTVISWRGAV IEPEQGTELP  60
   61 SRRAEVPTKP PLPPARTQGT PVHLNYRQKG VIDVFLHAWK GYRKFAWGHD ELKPVSRSFS 120
  121 EWFGLGLTLI DALDTMWILG LRKEFEEARK WVSKKLHFEK DVDVNLFEST IRILGGLLSA 180
  181 YHLSGDSLFL RKAEDFGNRL MPAFRTPSKI PYSDVNIGTG VAHPPRWTSD STVAEVTSIQ 240
  241 LEFRELSRLT GDKKFQEAVE KVTQHIHGLS GKKDGLVPMF INTHSGLFTH LGVFTLGARA 300
  301 DSYYEYLLKQ WIQGGKQETQ LLEDYVEAIE GVRTHLLRHS EPSKLTFVGE LAHGRFSAKM 360
  361 DHLVCFLPGT LALGVYHGLP ASHMELAQEL METCYQMNRQ METGLSPEIV HFNLYPQPGR 420
  421 RDVEVKPADR HNLLRPETVE SLFYLYRVTG DRKYQDWGWE ILQSFSRFTR VPSGGYSSIN 480
  481 NVQDPQKPEP RDKMESFFLG ETLKYLFLLF SDDPNLLSLD AYVFNTEAHP LPIWTPA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1000.0
Match: 1x9dA
Description: Crystal Structure Of Human Class I alpha-1,2-Mannosidase In Complex With Thio-Disaccharide Substrate Analogue
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
mannosyl-oligosaccharide mannosidase activity 7.089685350864 bayes_pls_golite062009
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity 6.95179264736435 bayes_pls_golite062009
mannosidase activity 5.20286438265852 bayes_pls_golite062009
hydrolase activity, hydrolyzing O-glycosyl compounds 4.31319275372149 bayes_pls_golite062009
hydrolase activity, acting on glycosyl bonds 3.65589746311782 bayes_pls_golite062009
hydrolase activity 2.67964748309919 bayes_pls_golite062009
binding 1.49199031708525 bayes_pls_golite062009
catalytic activity 1.31873306707813 bayes_pls_golite062009
cation binding 0.362242764130218 bayes_pls_golite062009
metal ion binding 0.362242764130218 bayes_pls_golite062009
protein binding 0.36081692928767 bayes_pls_golite062009
ion binding 0.355220167272296 bayes_pls_golite062009
calcium ion binding 0.121126738064555 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle