YRC Public Data Repository - Protein Structure Prediction

Protein:	HECTD2
Organism:	Homo sapiens
Length:	776 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HECTD2.

Description	E-value	Query Range	Subject Range
HECD2_PONAB - Probable E3 ubiquitin-protein ligase HECTD2 OS=Pongo abelii GN=HECTD2 PE=2 SV=1 HECD2_PONPY - Probable E3 ubiquitin-protein ligase HECTD2 - Pongo pygmaeus (Orangutan)	916.0	[0..1]	[776..1]
gi\|190690357, gi... - gi\|190691739\|gb\|ACE87644.1\| HECT domain containing 2 protein [synthetic construct], gi\|190690357\|gb\|... gi\|33342280, gi\|... - gi\|54673656\|gb\|AAH40187.1\| HECT domain containing 2 [Homo sapiens], gi\|33342280\|ref\|NP_877497.1\| HEC...	912.0	[0..1]	[776..1]
gi\|109089912 - gi\|109089912\|ref\|XP_001088322.1\| PREDICTED: similar to HECT domain containing 2 isoform a [Macaca mu...	900.0	[0..1]	[776..1]
gi\|109463807 - gi\|109463807\|ref\|XP_001080559.1\| PREDICTED: similar to HECT domain containing 2 [Rattus norvegicus]	866.0	[0..1]	[776..1]
HECD2_MOUSE - Probable E3 ubiquitin-protein ligase HECTD2 OS=Mus musculus GN=Hectd2 PE=2 SV=1	856.0	[0..1]	[776..1]
gi\|73998185 - gi\|73998185\|ref\|XP_543924.2\| PREDICTED: similar to HECT domain containing 2 isoform a [Canis familia...	848.0	[0..1]	[776..1]
gi\|76654517 - gi\|76654517\|ref\|XP_599002.2\| PREDICTED: similar to HECT domain containing 2 isoform a [Bos taurus]	812.0	[0..36]	[776..52]
gi\|85110577 - gi\|85110577\|ref\|XP_963528.1\| hypothetical protein NCU06756 [Neurospora crassa OR74A] gi\|32413124, gi\|... - gi\|32413124\|ref\|XP_327042.1\| hypothetical protein [Neurospora crassa], gi\|28925211\|gb\|EAA34292.1\| co...	662.0	[0..12]	[776..438]
gi\|67516325, gi\|... - gi\|67516325\|ref\|XP_658048.1\| hypothetical protein AN0444.2 [Aspergillus nidulans FGSC A4], ref\|XP_40...	653.0	[0..15]	[776..287]

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Predicted Domain #1

Region A:
Residues: [1-89]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEAVRVPSP ATPLVVAAPA PEERKGKESE REKLPPIVSA GAGATAGLDR GAKGQISTFS  60
   61 SFISAVSPKK EAAENRSSPA HLVFPNIKN

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [90-245]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VREPPPICLD VRQKQRTSMD ASSSEMKAPV LPEPILPIQP KTVKDFQEDV EKVKSSGDWK  60
   61 AVHDFYLTTF DSFPELNAAF KKDATASFNT IEDSGINAKF VNAVYDTLLN TPQDVQKTVL 120
  121 KGIINSLLRE WKGPRTKDDL RAYFILLQNP QFNNTS

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [246-406]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TYVIYAHLLR QIATLVEADH HFLVHWFKKL SQKRFKQLVE RLLQFISLRL FPAKPEEFPP  60
   61 ITKCSWWIPS AAKVLALLNT ANNLVHPPLI PYTDFYNSTL DHIDLMEEYH TWQNFGNSHR 120
  121 FSFCQYPFVI SVAAKKIIIQ RDSEQQMINI ARQSLVDKVS R

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4

Region A:
Residues: [407-776]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RQRPDMNILF LNMKVRRTHL VSDSLDELTR KRADLKKKLK VTFVGEAGLD MGGLTKEWFL  60
   61 LLIRQIFHPD YGMFTYHKDS HCHWFSSFKC DNYSEFRLVG ILMGLAVYNS ITLDIRFPPC 120
  121 CYKKLLSPPI IPSDQNIPVG ICNVTVDDLC QIMPELAHGL SELLSHEGNV EEDFYSTFQV 180
  181 FQEEFGIIKS YNLKPGGDKI SVTNQNRKEY VQLYTDFLLN KSIYKQFAAF YYGFHSVCAS 240
  241 NALMLLRPEE VEILVCGSPD LDMHALQRST QYDGYAKTDL TIKYFWDVVL GFPLDLQKKL 300
  301 LHFTTGSDRV PVGGMADLNF KISKNETSTN CLPVAHTCFN QLCLPPYKSK KDLKQKLIIG 360
  361 ISNSEGFGLE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	119.0
Match:	1c4zA
Description:	Ubiquitin-protein ligase E3a, Hect catalytic domain (E6ap)
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits