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View Structure Prediction Details

Protein: AP2A1_ARATH
Organism: Arabidopsis thaliana
Length: 1012 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AP2A1_ARATH.

Description E-value Query
Range
Subject
Range
AP2A2_ARATH - AP-2 complex subunit alpha-2 OS=Arabidopsis thaliana GN=ALPHAC-AD PE=1 SV=1
742.0 [0..1] [1012..1]

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Predicted Domain #1
Region A:
Residues: [1-66]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTGMRGLSVF ISDVRNCQNK EAERLRVDKE LGNIRTCFKN EKVLTPYKKK KYVWKMLYIH  60
   61 MLGYDV

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.4
Match: 1w63A
Description: AP1 clathrin adaptor core
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [67-655]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DFGHMEAVSL ISAPKYPEKQ VGYIVTSCLL NENHDFLKLA INTVRNDIIG RNETFQCLAL  60
   61 TLVGNIGGRD FAESLAPDVQ KLLISSSCRP LVRKKAALCL LRLFRKNPDA VNVDGWADRM 120
  121 AQLLDERDLG VLTSSTSLLV ALVSNNHEAY SSCLPKCVKI LERLARNQDV PQEYTYYGIP 180
  181 SPWLQVKAMR ALQYFPTIED PSTRKALFEV LQRILMGTDV VKNVNKNNAS HAVLFEALSL 240
  241 VMHLDAEKEM MSQCVALLGK FISVREPNIR YLGLENMTRM LMVTDVQDII KKHQSQIITS 300
  301 LKDPDISIRR RALDLLYGMC DVSNAKDIVE ELLQYLSTAE FSMREELSLK AAILAEKFAP 360
  361 DLSWYVDVIL QLIDKAGDFV SDDIWFRVVQ FVTNNEDLQP YAASKAREYL DKIAIHETMV 420
  421 KVSAYILGEY GHLLARQPGC SASELFSILH EKLPTISTPT IPILLSTYAK LLMHAQPPDP 480
  481 ELQKKVWAVF KKYESCIDVE IQQRAVEYFE LSKKGPAFMD VLAEMPKFPE RQSSLIKKAE 540
  541 NVEDTADQSA IKLRAQQQPS NAMVLADQQP VNGAPPPLKV PILSGSTDP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 49.221849
Match: 2iaeA
Description: No description for 2iaeA was found.

Predicted Domain #3
Region A:
Residues: [656-727]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ESVARSLSHP NGTLSNIDPQ TPSPDLLSDL LGPLAIEAPP GAVSNEQHGP VGAEGVPDEV  60
   61 DGSAIVPVEE QT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [728-1012]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NTVELIGNIA ERFHALCLKD SGVLYEDPHI QIGIKAEWRG HHGRLVLFMG NKNTSPLTSV  60
   61 QALILPPAHL RLDLSPVPDT IPPRAQVQSP LEVMNIRPSR DVAVLDFSYK FGANVVSAKL 120
  121 RIPATLNKFL QPLQLTSEEF FPQWRAISGP PLKLQEVVRG VRPLALPEMA NLFNSFHVTI 180
  181 CPGLDPNPNN LVASTTFYSE STGAILCLAR IETDPADRTQ LRMTVGTGDP TLTFELKEFI 240
  241 KEQLITVPMG SRALVPAAGP APPVAQPPSP AALADDPGAM LAGLL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 81.69897
Match: 1w80A
Description: Crystal structure of the alpha-adaptin appendage domain, from the AP2 adaptor complex, bound to 2 peptides from Synaptojanin170
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle