YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|157830127, gi...
Organism:	Homo sapiens
Length:	146 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|157830127, gi....

Description	E-value	Query Range	Subject Range
gi\|46854316 - gi\|46854316\|gb\|AAH69323.1\| Leptin [Homo sapiens]	248.0	[0..1]	[146..22]
gi\|56001057 - gi\|56001057\|emb\|CAI23842.1\| leptin precursor [Sus scrofa domestica] LEP_PIG - Leptin OS=Sus scrofa GN=LEP PE=2 SV=1 gi\|55741433 - ref\|NP_999005.1\| leptin [Sus scrofa]	247.0	[0..1]	[146..22]
gi\|114615809 - gi\|114615809\|ref\|XP_519353.2\| PREDICTED: leptin [Pan troglodytes] sp\|P41159-1\|LEP_... - Leptin OS=Homo sapiens GN=LEP PE=1 SV=1 VAR_004197, Leptin OS=Homo sapiens GN=LEP PE=1 SV=1 VAR_0041...	246.0	[0..1]	[146..22]
LEP_FELCA - Leptin OS=Felis catus GN=LEP PE=2 SV=1	244.0	[0..1]	[146..22]
LEP_URSTH - Leptin OS=Ursus thibetanus GN=LEP PE=2 SV=1 gi\|90990839 - gi\|90990839\|dbj\|BAE92862.1\| leptin [Ursus thibetanus japonicus]	242.0	[0..1]	[146..22]

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Predicted Domain #1

Region A:
Residues: [1-146]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPIQKVQDDT KTLIKTIVTR INDISHTQSV SSKQKVTGLD FIPGLHPILT LSKMDQTLAV  60
   61 YQQILTSMPS RNVIQISNDL ENLRDLLHVL AFSKSCHLPE ASGLETLDSL GGVLEASGYS 120
  121 TEVVALSRLQ GSLQDMLWQL DLSPGC

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Detection Method:	PSI-BLAST
Confidence:	62.69897
Match:	1ax8A
Description:	HUMAN OBESITY PROTEIN, LEPTIN
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
cytokine receptor binding	6.47223189691244	bayes_pls_golite062009
receptor binding	5.3304255990112	bayes_pls_golite062009
cytokine activity	5.1883241815362	bayes_pls_golite062009
growth factor activity	3.72884804690203	bayes_pls_golite062009
protein binding	3.26483713001551	bayes_pls_golite062009
hormone activity	2.52921243340076	bayes_pls_golite062009
binding	2.48265117231403	bayes_pls_golite062009
prolactin receptor binding	2.45721634350294	bayes_pls_golite062009
interleukin-6 receptor binding	1.35761970306312	bayes_pls_golite062009
growth hormone activity	0.858583061924711	bayes_pls_golite062009
interleukin-27 binding	0.814859517857	bayes_pls_golite062009
ciliary neurotrophic factor receptor binding	0.749565138698391	bayes_pls_golite062009
catalytic activity	0.246169290135575	bayes_pls_golite062009
macrophage colony stimulating factor receptor binding	0.227887473647222	bayes_pls_golite062009
interleukin-12 binding	0.17299185486948	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: