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View Structure Prediction Details

Protein: gi|162318718, gi...
Organism: synthetic construct
Length: 1230 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|162318718, gi....

Description E-value Query
Range
Subject
Range
gi|10442756 - gi|10442756|gb|AAG17468.1|AF183187_1 heart/fetal otoferlin [Homo sapiens]
0.0 [1..1230] [1..1230]
OTOF_RAT - Otoferlin OS=Rattus norvegicus GN=Otof PE=1 SV=2
0.0 [1..1230] [763..1993]
gi|10119912 - gi|10119912|gb|AAG12989.1|AF183183_1 cochlear otoferlin [Mus musculus]
0.0 [1..1230] [762..1992]
gi|73979879 - gi|73979879|ref|XP_859651.1| PREDICTED: similar to otoferlin isoform b isoform 3 [Canis familiaris]
0.0 [1..1230] [1..1230]

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Predicted Domain #1
Region A:
Residues: [1-194]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIKTEKSYPE RRLRGVLEEL SCGCCRFLSL ADKDQGHSSR TRLDRERLKS CMRELENMGQ  60
   61 QARMLRAQVK RHTVRDKLRL CQNFLQKLRF LADEPQHSIP DIFIWMMSNN KRVAYARVPS 120
  121 KDLLFSIVEE ETGKDCAKVK TLFLKLPGKR GFGSAGWTVQ AKVELYLWLG LSKQRKEFLC 180
  181 GLPCGFQEVK AAQG

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.01
Match: 1sl6A
Description: Crystal Structure of a fragment of DC-SIGNR (containg the carbohydrate recognition domain and two repeats of the neck) complexed with Lewis-x.
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [195-310]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LGLHAFPPVS LVYTKKQAFQ LRAHMYQARS LFAADSSGLS DPFARVFFIN QSQCTEVLNE  60
   61 TLCPTWDQML VFDNLELYGE AHELRDDPPI IVIEIYDQDS MGKADFMGRT FAKPLV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 51.39794
Match: 1dqvA
Description: Synaptogamin I
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [311-834]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KMADEAYCPP RFPPQLEYYQ IYRGNATAGD LLAAFELLQI GPAGKADLPP INGPVDVDRG  60
   61 PIMPVPMGIR PVLSKYRVEV LFWGLRDLKR VNLAQVDRPR VDIECAGKGV QSSLIHNYKK 120
  121 NPNFNTLVKW FEVDLPENEL LHPPLNIRVV DCRAFGRYTL VGSHAVSSLR RFIYRPPDRS 180
  181 APSWNTTGEV VVTMEPEVPI KKLETMVKLD ATSEAVVKVD VAEEEKEKKK KKKGTAEEPE 240
  241 EEEPDESMLD WWSKYFASID TMKEQLRQQE PSGIDLEEKE EVDNTEGLKG SMKGKEKARA 300
  301 AKEEKKKKTQ SSGSGQGSEA PEKKKPKIDE LKVYPKELES EFDNFEDWLH TFNLLRGKTG 360
  361 DDEDGSTEEE RIVGRFKGSL CVYKVPLPED VSREAGYDST YGMFQGIPSN DPINVLVRVY 420
  421 VVRATDLHPA DINGKADPYI AIRLGKTDIR DKENYISKQL NPVFGKSFDI EASFPMESML 480
  481 TVAVYDWDLV GTDDLIGETK IDLENRFYSK HRATCGIAQT YSTH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 31.69897
Match: 2fjuB
Description: No description for 2fjuB was found.

Predicted functions:

Term Confidence Notes
catalytic activity 0.693222330136336 bayes_pls_golite062009
hydrolase activity 0.17768980721334 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 0.05056572092175 bayes_pls_golite062009
phosphoric ester hydrolase activity 0.0304825793447705 bayes_pls_golite062009
phosphoric diester hydrolase activity 0.01534375493934 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [835-927]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GYNIWRDPMK PSQILTRLCK DGKVDGPHFG PPGRVKVANR VFTGPSEIED ENGQRKPTDE  60
   61 HVALLALRHW EDIPRAGCRL VPEHVETRPL LNP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [928-1108]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DKPGIEQGRL ELWVDMFPMD MPAPGTPLDI SPRKPKKYEL RVIIWNTDEV VLEDDDFFTG  60
   61 EKSSDIFVRG WLKGQQEDKQ DTDVHYHSLT GEGNFNWRYL FPFDYLAAEE KIVISKKESM 120
  121 FSWDETEYKI PARLTLQIWD ADHFSADDFL GAIELDLNRF PRGAKTAKQC TMEMATGEVD 180
  181 V

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.30103
Match: 2b3rA
Description: Crystal structure of the C2 domain of class II phosphatidylinositide 3-kinase C2
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [1109-1230]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLVSIFKQKR VKGWWPLLAR NENDEFELTG KVEAELHLLT AEEAEKNPVG LARNEPDPLE  60
   61 KPNRPDTAFV WFLNPLKSIK YLICTRYKWL IIKIVLALLG LLMLGLFLYS LPGYMVKKLL 120
  121 GA

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.01
Match: 2dmhA
Description: No description for 2dmhA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle