YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|337491
Organism:	Homo sapiens
Length:	520 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|337491.

Description	E-value	Query Range	Subject Range
gi\|109124742 - gi\|109124742\|ref\|XP_001093024.1\| PREDICTED: v-akt murine thymoma viral oncogene homolog 2 isoform 2 ...	475.0	[0..1]	[478..1]
gi\|114677289, gi... - gi\|114677295\|ref\|XP_001143709.1\| PREDICTED: v-akt murine thymoma viral oncogene homolog 2 isoform 12...	474.0	[0..1]	[478..1]
AKT2 - v-akt murine thymoma viral oncogene homolog 2	472.0	[0..1]	[478..1]
gi\|76641330 - gi\|76641330\|ref\|XP_870006.1\| PREDICTED: similar to RAC-beta serine/threonine-protein kinase (RAC-PK-...	471.0	[0..1]	[478..1]
gi\|149056511, gi... - gi\|76365214\|gb\|ABA42095.1\| protein kinase B beta [Rattus norvegicus], gi\|149056513\|gb\|EDM07944.1\| th...	468.0	[0..1]	[478..1]
gi\|117616192 - gi\|117616192\|gb\|ABK42114.1\| Akt2 [synthetic construct] AKT2_MOUSE - RAC-beta serine/threonine-protein kinase OS=Mus musculus GN=Akt2 PE=1 SV=1	467.0	[0..1]	[478..1]

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Predicted Domain #1

Region A:
Residues: [1-126]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNEVSVIKEG WLHKRGEYIK TWRPRYFLLK SDGSFIGYKE RPEAPDQTLP PLNNFSVAEC  60
   61 QLMKTERPRP NTFVIRCLQW TTVIERTFHV DSPDEREEWM RAIQMVANSL KQRAPGEDPM 120
  121 DYKCGS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	25.154902
Match:	1p6sA
Description:	Solution Structure of the Pleckstrin Homology Domain of Human Protein Kinase B beta (Pkb/Akt)
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [127-520]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSDSSTTEEM EVAVSKARAK VTMNDFDYLK LLGKGTFGKV ILVREKATGR YYAMKILRKE  60
   61 VIIAKDEVAH TVTESRVLQN TRHPFLTALK YAFQTHDRLC FVMEYANGGE LFFHLSRERV 120
  121 FTEERARFYG AEIVSALEYL HSRDVVYRDI KLENLMLDKD GHIKITDFGL CKEGISDGAT 180
  181 MKTFCGTPEY LAPEVLEDND YGRAVDWWGL GVVMYEMMCG RLPFYNQDHE RLFELILMEE 240
  241 IRFPRTLSPE AKSLLAGLLK KDPKQRLGGG PSDAKEVMEH RFFLSINWQD VVQKKLLPPF 300
  301 KPQVTSEVDT RYFDDEFTAQ SITITPPDRY DSLGLLELDQ RTHFPQFSYS AFREEKDLLM 360
  361 SLFVSLILFS DFSSLKSHSF SSNFILLSFS SLKK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	98.522879
Match:	1mrvA
Description:	crystal structure of an inactive Akt2 kinase domain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits