YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|15724228, gi\|...
Organism:	Arabidopsis thaliana
Length:	666 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|15724228, gi|....

Description	E-value	Query Range	Subject Range
gi\|113564697, gi... - gi\|115459052\|ref\|NP_001053126.1\| Os04g0483600 [Oryza sativa (japonica cultivar-group)], gi\|113564697...	422.0	[0..13]	[666..13]
gi\|116310471 - gi\|116310471\|emb\|CAH67474.1\| H0805A05.4 [Oryza sativa (indica cultivar-group)]	418.0	[0..15]	[638..15]
gi\|169770067 - gi\|169770067\|ref\|XP_001819503.1\| hypothetical protein [Aspergillus oryzae RIB40] gi\|83767362 - gi\|83767362\|dbj\|BAE57501.1\| unnamed protein product [Aspergillus oryzae]	380.0	[0..1]	[666..1]
gi\|114192067, gi... - gi\|115399190\|ref\|XP_001215184.1\| conserved hypothetical protein [Aspergillus terreus NIH2624], gi\|11...	378.0	[0..1]	[665..1]
gi\|70989557, gi\|... - gi\|70989557\|ref\|XP_749628.1\| Kelch repeats protein [Aspergillus fumigatus Af293], gi\|66847259\|gb\|EAL... gi\|159129034 - gi\|159129034\|gb\|EDP54148.1\| Kelch repeats protein, putative [Aspergillus fumigatus A1163]	373.0	[0..1]	[665..1]
gi\|67523267, gi\|... - gi\|67523267\|ref\|XP_659694.1\| hypothetical protein AN2090.2 [Aspergillus nidulans FGSC A4], ref\|XP_40...	371.0	[0..1]	[665..1]
gi\|70868456 - gi\|70868456\|gb\|EAN83308.1\| hypothetical protein, conserved [Trypanosoma cruzi] gi\|71405008 - gi\|71405008\|ref\|XP_805159.1\| hypothetical protein [Trypanosoma cruzi strain CL Brener]	368.0	[0..2]	[662..4]
gi\|149038370, gi... - gi\|149038370\|gb\|EDL92730.1\| rCG51065, isoform CRA_a [Rattus norvegicus], gi\|109509005\|ref\|XP_0010791...	361.0	[0..36]	[634..32]

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Predicted Domain #1

Region A:
Residues: [1-409]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKKTKKPGK GKEKTERKTA KADEKKARRE GKKLSPEDDI DAILLNIQKE EAKKKEVHVE  60
   61 ENVAAPSPRS NCSLTINPLK ETELILYGGE FYNGQKTYVY GDLYRYDVEK QEWKLVSSPN 120
  121 SPPPRSSHQA VAWKNYLYIF GGEFTSPNQE RFHHYKDFWM LDVKTNQWEQ LNLKGCPSPR 180
  181 SGHRMVLYKH KIIIFGGFYD TLREVRYYND LYVFDLDQYK WQEIKPKPGA MWPTARSGFQ 240
  241 FFVYQDEIFL YGGYSKEVSS EKSSEKGIVH ADLWSLDPRT WEWNKVKKIG MPPSSRAGFS 300
  301 VCVHKKRALL FGGVVDMEME GDVMMSLFLN ELYGFQLDNR RWYPIELRKE KSSKDKAKKT 360
  361 LEAKPVASNN DDEMDSTEED ESLAMIEQTD GVGSSDGISE RMATNLTVD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	66.0
Match:	1x2jA
Description:	Structural basis for the defects of human lung cancer somatic mutations in the repression activity of Keap1 on Nrf2
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [410-541]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNRSDKSKAL QGAKTRLDPQ VSVSEEVVKP CGRINSCMVV GKDTLYIYGG MMEIKDKEVT  60
   61 LDDLYSLNLS KLDEWKCIIP TTETEWVEVS DDEEGDEDDD EDDSEDEGNS EESDDEDDDE 120
  121 EVEAMDVDGS VK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	64.154902
Match:	1zgkA
Description:	1.35 angstrom structure of the Kelch domain of Keap1
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [542-666]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VGVVVAMIKG QGKSLRRKEK RARIEQIRAN LGLSDSQRTP VPGETLKDFY KRTNMYWQMA  60
   61 AYEHTQHTGK ELRKDGFDLA ETRYLELKPI LDELAILEAE QKAEEAEGPE ASSSSRKGGI 120
  121 AKKKR

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.850	a.121.1	Tetracyclin repressor-like, C-terminal domain

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits