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View Structure Prediction Details

Protein: gi|190406141
Organism: Saccharomyces cerevisiae RM11-1a
Length: 377 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|190406141.

Description E-value Query
Range		 Subject
Range
SEN2 - Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; S...
gi|190406141 - gi|190406141|gb|EDV09408.1| tRNA splicing endonuclease subunit [Saccharomyces cerevisiae RM11-1a]
SEN2_YEAST - tRNA-splicing endonuclease subunit SEN2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=...
gi|151941272 - gi|151941272|gb|EDN59650.1| tRNA splicing endonuclease subunit [Saccharomyces cerevisiae YJM789]
 0.0 [1..377] [1..377]
sen2 - tRNA-splicing endonuclease subunit Sen2
SEN2_SCHPO - Probable tRNA-splicing endonuclease subunit sen2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 248...
 0.0 [7..377] [4..380]
gi|114679004, gi... - gi|114679014|ref|XP_001174914.1| PREDICTED: hypothetical protein isoform 2 [Pan troglodytes], gi|114...
TSEN34 - tRNA splicing endonuclease 34 homolog (S. cerevisiae)
 1.0E-61 [96..350] [73..308]
SEN22_ARATH - tRNA-splicing endonuclease subunit Sen2-2 OS=Arabidopsis thaliana GN=SEN2 PE=2 SV=1
 3.0E-55 [155..377] [8..231]
SEN34_MOUSE - tRNA-splicing endonuclease subunit Sen34 OS=Mus musculus GN=Tsen34 PE=2 SV=2
 9.0E-49 [96..350] [41..314]

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Predicted Domain #1
Region A:
Residues: [1-155] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKGRVNQKR YKYPLPIHPV DDLPELILHN PLSWLYWAYR YYKSTNALND KVHVDFIGDT  60
   61 TLHITVQDDK QMLYLWNNGF FGTGQFSRSE PTWKARTEAR LGLNDTPLHN RGGTKSNTET 120
  121 EMTLEKVTQQ RRLQRLEFKK ERAKLERELL ELRKK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [156-260] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGHIDEENIL LEKQRESLRK FKLKQTEDVG IVAQQQDISE SNLRDEDNNL LDENGDLLPL  60
   61 ESLELMPVEA MFLTFALPVL DISPACLAGK LFQFDAKYKD IHSFV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 67.529817
Match: 1a79A_
Description: tRNA splicing endonuclease, C-terminal domain; tRNA splicing endonuclease EdnA, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.47870548102815 bayes_pls_golite062009
protein binding 0.382621269105676 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [261-377] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RSYVIYHHYR SHGWCVRSGI KFGCDYLLYK RGPPFQHAEF CVMGLDHDVS KDYTWYSSIA  60
   61 RVVGGAKKTF VLCYVERLIS EQEAIALWKS NNFTKLFNSF QVGEVLYKRW VPGRNRD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 67.529817
Match: 1a79A_
Description: tRNA splicing endonuclease, C-terminal domain; tRNA splicing endonuclease EdnA, N-terminal domain
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle