YRC Public Data Repository - Protein Structure Prediction

Protein:	HEM1_SALEP
Organism:	Salmonella enterica subsp. enterica serovar Enteritidis str. P125109
Length:	418 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HEM1_SALEP.

Description	E-value	Query Range	Subject Range
gi\|237705171, gi... - gi\|237705171\|ref\|ZP_04535652.1\| glutamyl-tRNA reductase [Escherichia sp. 3_2_53FAA], gi\|226899928\|gb... gi\|26107934, gi\|... - gi\|26247533\|ref\|NP_753573.1\| glutamyl-tRNA reductase [Escherichia coli CFT073], gi\|26107934\|gb\|AAN80... gi\|91072005, gi\|... - gi\|91210431\|ref\|YP_540417.1\| glutamyl-tRNA reductase [Escherichia coli UTI89], gi\|91072005\|gb\|ABE068...	0.0	[1..418]	[67..484]
gi\|110614763, gi... - gi\|110805215\|ref\|YP_688735.1\| glutamyl-tRNA reductase [Shigella flexneri 5 str. 8401], gi\|110614763\|... gi\|24112609, gi\|... - ref\|NP_707119.1\| glutamyl-tRNA reductase [Shigella flexneri 2a str. 301], gb\|AAN42826.1\| glutamyl-t...	0.0	[1..418]	[67..484]
gi\|154103 - gi\|154103\|gb\|AAA88610.1\| hemA gene product gi\|154103\|gb\|AAA... - hemA gene product	0.0	[1..418]	[1..418]
HEM1_SALCH - Glutamyl-tRNA reductase OS=Salmonella choleraesuis GN=hemA PE=3 SV=1 HEM1_SALCH - Glutamyl-tRNA reductase OS=Salmonella choleraesuis (strain SC-B67) GN=hemA PE=3 SV=1 HEM1_SALCH - Glutamyl-tRNA reductase OS=Salmonella choleraesuis GN=hemA PE=3 SV=1	0.0	[1..418]	[1..418]
gi\|1651600, gi\|8... - gi\|89108055\|ref\|AP_001835.1\| glutamyl tRNA reductase [Escherichia coli str. K-12 substr. W3110], gi\|... HEM1_ECOLI - Glutamyl-tRNA reductase (EC 1.2.1.70) (GluTR) - Escherichia coli gi\|13361180, gi\|... - gi\|15830969\|ref\|NP_309742.1\| glutamyl-tRNA reductase [Escherichia coli O157:H7 str. Sakai], gi\|13361... HEM1_ECOBW - Glutamyl-tRNA reductase OS=Escherichia coli (strain K12 / MC4100 / BW2952) GN=hemA PE=3 SV=1 gi\|208737546, gi... - gi\|208822061\|ref\|ZP_03262380.1\| glutamyl-tRNA reductase [Escherichia coli O157:H7 str. EC4042], gi\|2... gi\|254592080, gi... - gi\|254792680\|ref\|YP_003077517.1\| glutamyl tRNA reductase [Escherichia coli O157:H7 str. TW14359], gi... HEM1_ECO5E - Glutamyl-tRNA reductase OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=hemA PE=3 SV=1 HEM1_ECO57 - Glutamyl-tRNA reductase OS=Escherichia coli O157:H7 GN=hemA PE=3 SV=1 gi\|217318469, gi... - gi\|217328042\|ref\|ZP_03444124.1\| glutamyl-tRNA reductase [Escherichia coli O157:H7 str. TW14588], gi\|... EG10427 - glutamyl tRNA reductase / Glutamyl-tRNA reductase, hemin biosynthesis; neomycin sensitivity HEM1_ECOLU - Glutamyl-tRNA reductase OS=Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC) GN=hemA PE=3 SV=1 gi\|188015100, gi... - gi\|188015100\|gb\|EDU53222.1\| glutamyl-tRNA reductase [Escherichia coli O157:H7 str. EC4113], gi\|16875... gi\|168776897, gi... - gi\|187767799\|gb\|EDU31643.1\| glutamyl-tRNA reductase [Escherichia coli O157:H7 str. EC4196], gi\|16877... gi\|189000013, gi... - gi\|189000013\|gb\|EDU68999.1\| glutamyl-tRNA reductase [Escherichia coli O157:H7 str. EC4076], gi\|16878... HEM1_ECODH - Glutamyl-tRNA reductase OS=Escherichia coli (strain K12 / DH10B) GN=hemA PE=3 SV=1 EG10427 - glutamyl tRNA reductase / Glutamyl-tRNA reductase, hemin biosynthesis; neomycin sensitivity gi\|193069944, gi... - gi\|75235278\|ref\|ZP_00719515.1\| COG0373: Glutamyl-tRNA reductase [Escherichia coli E110019], gi\|19306... gi\|195939098 - gi\|195939098\|ref\|ZP_03084480.1\| glutamyl-tRNA reductase [Escherichia coli O157:H7 str. EC4024] gi\|208726581, gi... - gi\|208806780\|ref\|ZP_03249117.1\| glutamyl-tRNA reductase [Escherichia coli O157:H7 str. EC4206], gi\|2... gi\|208814821, gi... - gi\|208814821\|ref\|ZP_03256000.1\| glutamyl-tRNA reductase [Escherichia coli O157:H7 str. EC4045], gi\|2...	0.0	[1..418]	[1..418]
gi\|15801439, gi\|... - gi\|15801439\|ref\|NP_287456.1\| glutamyl-tRNA reductase [Escherichia coli O157:H7 EDL933], gi\|12514923\|... gi\|25286556 - gi\|25286556\|pir\|\|H85700 hypothetical protein hemA [imported] - Escherichia coli (strain O157:H7, su...	0.0	[1..418]	[1..418]
HEM1_ESCF3 - Glutamyl-tRNA reductase OS=Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73) GN=h... gi\|83569314 - gi\|83569314\|ref\|ZP_00920770.1\| COG0373: Glutamyl-tRNA reductase [Shigella dysenteriae 1012]	0.0	[1..418]	[1..418]
gi\|194437120, gi... - gi\|83587354\|ref\|ZP_00925982.1\| COG0373: Glutamyl-tRNA reductase [Escherichia coli 101-1], gi\|1944371... HEM1_ECOLC - Glutamyl-tRNA reductase OS=Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) GN=hemA PE=3 SV=1 gi\|253977407, gi... - gi\|254288100\|ref\|YP_003053848.1\| glutamyl-tRNA reductase [Escherichia coli BL21(DE3)], gi\|253977407\|... gi\|124528407, gi... - gi\|124528407\|ref\|ZP_01699717.1\| Shikimate/quinate 5-dehydrogenase [Escherichia coli B], gi\|124500639... gi\|251784716, gi... - gi\|251784716\|ref\|YP_002999020.1\| hypothetical protein B21_01195 [Escherichia coli BL21], gi\|24237698... gi\|254161292, gi... - gi\|254161292\|ref\|YP_003044400.1\| glutamyl-tRNA reductase [Escherichia coli B str. REL606], gi\|253973... gi\|188494819, gi... - gi\|75511754\|ref\|ZP_00734383.1\| COG0373: Glutamyl-tRNA reductase [Escherichia coli 53638], gi\|1884948... HEM1_ECOHS - Glutamyl-tRNA reductase OS=Escherichia coli O9:H4 (strain HS) GN=hemA PE=3 SV=1	0.0	[1..418]	[1..418]
HEM1_ECO45 - Glutamyl-tRNA reductase OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=hemA PE=3 SV=1 HEM1_ECO81 - Glutamyl-tRNA reductase OS=Escherichia coli O81 (strain ED1a) GN=hemA PE=3 SV=1 HEM1_ECOL6 - Glutamyl-tRNA reductase OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=hemA PE=3 ... gi\|227836572, gi... - gi\|227886368\|ref\|ZP_04004173.1\| glutamyl-tRNA reductase [Escherichia coli 83972], gi\|227836572\|gb\|EE... gi\|75242014, gi\|... - gi\|75242014\|ref\|ZP_00725808.1\| COG0373: Glutamyl-tRNA reductase [Escherichia coli F11], gi\|191171014... HEM1_ECOL6 - Glutamyl-tRNA reductase OS=Escherichia coli O6 GN=hemA PE=3 SV=2 HEM1_ECOUT - Glutamyl-tRNA reductase OS=Escherichia coli (strain UTI89 / UPEC) GN=hemA PE=3 SV=2	0.0	[1..418]	[1..418]
HEM1_SHIDS - Glutamyl-tRNA reductase OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=hemA PE=3 SV=1	0.0	[1..418]	[1..418]

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Predicted Domain #1

Region A:
Residues: [1-418]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTLLALGINH KTAPVSLRER VTFSPDTLDQ ALDSLLAQPM VQGGVVLSTC NRTELYLSVE  60
   61 EQDNLQEALI RWLCDYHNLN EDDLRNSLYW HQDNDAVSHL MRVASGLDSL VLGEPQILGQ 120
  121 VKKAFADSQK GHLNASALER MFQKSFSVAK RVRTETDIGA SAVSVAFAAC TLARQIFESL 180
  181 STVTVLLVGA GETIELVARH LREHKVQKMI IANRTRERAQ ALADEVGAEV ISLSDIDARL 240
  241 QDADIIISST ASPLPIIGKG MVERALKSRR NQPMLLVDIA VPRDVEPEVG KLANAYLYSV 300
  301 DDLQSIISHN LAQRQAAAVE AETIVEQEAS EFMAWLRAQG ASETIREYRS QSEQIRDELT 360
  361 TKALSALQQG GDAQAILQDL AWKLTNRLIH APTKSLQQAA RDGDDERLNI LRDSLGLE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	63.39794
Match:	1gpjA
Description:	Glutamyl tRNA-reductase dimerization domain; Glutamyl tRNA-reductase middle domain; Glutamyl tRNA-reductase catalytic, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.79741889688267	bayes_pls_golite062009
oxidoreductase activity	0.881088609158401	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: