YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|157928134, gi...
Organism:	synthetic construct
Length:	756 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|157928134, gi....

Description	E-value	Query Range	Subject Range
gi\|114585960, gi... - gi\|114585960\|ref\|XP_001170433.1\| PREDICTED: MutL protein homolog 1 isoform 8 [Pan troglodytes], gi\|1...	0.0	[1..756]	[1..756]
gi\|33303773 - gi\|33303773\|gb\|AAQ02400.1\| mutL-like 1, colon cancer, nonpolyposis type 2 [synthetic construct]	0.0	[1..756]	[1..756]
gi\|466462 - gi\|466462\|gb\|AAA17374.1\| human homolog of E. coli mutL gene product, Swiss-Prot Accession Number P23...	0.0	[1..756]	[1..756]
MLH1_MOUSE - DNA mismatch repair protein Mlh1 OS=Mus musculus GN=Mlh1 PE=1 SV=2	0.0	[1..756]	[1..760]
gi\|73989704 - gi\|73989704\|ref\|XP_534219.2\| PREDICTED: similar to MutL protein homolog 1 isoform 1 [Canis familiari...	0.0	[1..756]	[1..757]

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Predicted Domain #1

Region A:
Residues: [1-354]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFVAGVIRR LDETVVNRIA AGEVIQRPAN AIKEMIENCL DAKSTSIQVI VKEGGLKLIQ  60
   61 IQDNGTGIRK EDLDIVCERF TTSKLQSFED LASISTYGFR GEALASISHV AHVTITTKTA 120
  121 DGKCAYRASY SDGKLKAPPK PCAGNQGTQI TVEDLFYNIA TRRKALKNPS EEYGKILEVV 180
  181 GRYSVHNAGI SFSVKKQGET VADVRTLPNA STVDNIRSIF GNAVSRELIE IGCEDKTLAF 240
  241 KMNGYISNAN YSVKKCIFLL FINHRLVEST SLRKAIETVY AAYLPKNTHP FLYLSLEISP 300
  301 QNVDVNVHPT KHEVHFLHEE SILERVQQHI ESKLLGSNSS RMYFTQTLLP GLAG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	76.0
Match:	1bknA
Description:	DNA mismatch repair protein MutL
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [355-535]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSGEMVKSTT SLTSSSTSGS SDKVYAHQMV RTDSREQKLD AFLQPLSKPL SSQPQAIVTE  60
   61 DKTDISSGRA RQQDEEMLEL PAPAEVAAKN QSLEGDTTKG TSEMSEKRGP TSSNPRKRHR 120
  121 EDSDVEMVED DSRKEMTAAC TPRRRIINLT SVLSLQEEIN EQGHEVLREM LHNHSFVGCV 180
  181 N

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	21.30103
Match:	2cgeA
Description:	No description for 2cgeA was found.

Predicted Domain #3

Region A:
Residues: [536-756]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PQWALAQHQT KLYLLNTTKL SEELFYQILI YDFANFGVLR LSEPAPLFDL AMLALDSPES  60
   61 GWTEEDGPKE GLAEYIVEFL KKKAEMLADY FSLEIDEEGN LIGLPLLIDN YVPPLEGLPI 120
  121 FILRLATEVN WDEEKECFES LSKECAMFYS IRKQYISEES TLSGQQSEVP GSIPNSWKWT 180
  181 VEHIVYKALR SHILPPKHFT EDGNILQLAN LPDLYKVFER C

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.06
Match:	1x9zA
Description:	Crystal structure of the MutL C-terminal domain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits