YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|213163205
Organism:	Salmonella enterica subsp. enterica serovar Typhi str. E00-7866
Length:	309 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|213163205.

Description	E-value	Query Range	Subject Range
KHSE_ECO57 - Homoserine kinase OS=Escherichia coli O157:H7 GN=thrB PE=3 SV=1 gi\|217320485, gi... - gi\|217324264\|ref\|ZP_03440348.1\| homoserine kinase [Escherichia coli O157:H7 str. TW14588], gi\|217320... gi\|13359459, gi\|... - gi\|15829257\|ref\|NP_308030.1\| homoserine kinase [Escherichia coli O157:H7 str. Sakai], gi\|13359459\|db... KHSE_ECO5E - Homoserine kinase OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=thrB PE=3 SV=1 gi\|254791139, gi... - gi\|254791139\|ref\|YP_003075976.1\| homoserine kinase [Escherichia coli O157:H7 str. TW14359], gi\|25459... gi\|168797981, gi... - gi\|189379603\|gb\|EDU98019.1\| homoserine kinase [Escherichia coli O157:H7 str. EC508], gi\|168797981\|re... gi\|168785051, gi... - gi\|189374945\|gb\|EDU93361.1\| homoserine kinase [Escherichia coli O157:H7 str. EC869], gi\|168785051\|re... gi\|189000731, gi... - gi\|189000731\|gb\|EDU69717.1\| homoserine kinase [Escherichia coli O157:H7 str. EC4076], gi\|168781698\|r... gi\|168776613, gi... - gi\|187768016\|gb\|EDU31860.1\| homoserine kinase [Escherichia coli O157:H7 str. EC4196], gi\|168776613\|r... gi\|208738789, gi... - gi\|208818666\|ref\|ZP_03258986.1\| homoserine kinase [Escherichia coli O157:H7 str. EC4042], gi\|2087387... gi\|208735698, gi... - gi\|208814421\|ref\|ZP_03255750.1\| homoserine kinase [Escherichia coli O157:H7 str. EC4045], gi\|2087356... gi\|208807589, gi... - gi\|208807589\|ref\|ZP_03249926.1\| homoserine kinase [Escherichia coli O157:H7 str. EC4206], gi\|2087273... gi\|195937676 - gi\|195937676\|ref\|ZP_03083058.1\| homoserine kinase [Escherichia coli O157:H7 str. EC4024] gi\|168766690, gi... - gi\|189364315\|gb\|EDU82734.1\| homoserine kinase [Escherichia coli O157:H7 str. EC4486], gi\|168766690\|r... gi\|168762761, gi... - gi\|189366944\|gb\|EDU85360.1\| homoserine kinase [Escherichia coli O157:H7 str. EC4501], gi\|168762761\|r... gi\|189356095, gi... - gi\|189356095\|gb\|EDU74514.1\| homoserine kinase [Escherichia coli O157:H7 str. EC4401], gi\|168756826\|r... gi\|188014926, gi... - gi\|188014926\|gb\|EDU53048.1\| homoserine kinase [Escherichia coli O157:H7 str. EC4113], gi\|168750955\|r... gi\|12512678, gi\|... - gi\|15799683\|ref\|NP_285695.1\| homoserine kinase [Escherichia coli O157:H7 EDL933], gi\|12512678\|gb\|AAG... gi\|209747306, gi... - pir\|\|C85480 homoserine kinase [imported] - Escherichia coli (strain O157:H7, substrain EDL933), pir...	9.0E-73	[1..308]	[1..308]
KHSE_ECOUT - Homoserine kinase OS=Escherichia coli (strain UTI89 / UPEC) GN=thrB PE=3 SV=1 KHSE_ECO8A - Homoserine kinase OS=Escherichia coli O8 (strain IAI1) GN=thrB PE=3 SV=1 KHSE_ECOLC - Homoserine kinase OS=Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) GN=thrB PE=3 SV=1 KHSE_ECO45 - Homoserine kinase OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=thrB PE=3 SV=1 gi\|124530372, gi... - gi\|124530372\|ref\|ZP_01701058.1\| homoserine kinase [Escherichia coli B], gi\|124499263\|gb\|EAY46755.1\| ... gi\|194434152, gi... - gi\|194434152\|ref\|ZP_03066420.1\| homoserine kinase [Shigella dysenteriae 1012], gi\|194417589\|gb\|EDX33... KHSE_ECOK1 - Homoserine kinase OS=Escherichia coli O1:K1 / APEC GN=thrB PE=3 SV=1 KHSE_ECO27 - Homoserine kinase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=thrB PE=3 SV=1 KHSE_ECO55 - Homoserine kinase OS=Escherichia coli (strain 55989 / EAEC) GN=thrB PE=3 SV=1 KHSE_ECO7I - Homoserine kinase OS=Escherichia coli O7:K1 (strain IAI39 / ExPEC) GN=thrB PE=3 SV=1 sp\|B7UI48\|KHSE_ECO27 - Homoserine kinase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=thrB PE=3 SV=1 KHSE_SHIB3 - Homoserine kinase OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) GN=thrB PE=3 SV=1 KHSE_ECO24 - Homoserine kinase OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=thrB PE=3 SV=1 gi\|75229463, gi\|... - gi\|75229463\|ref\|ZP_00716013.1\| COG0083: Homoserine kinase [Escherichia coli B7A], gi\|191167386\|ref\|Z... gi\|193070623, gi... - gi\|75234566\|ref\|ZP_00718907.1\| COG0083: Homoserine kinase [Escherichia coli E110019], gi\|193070623\|r... KHSE_ECOHS - Homoserine kinase OS=Escherichia coli O9:H4 (strain HS) GN=thrB PE=3 SV=1 gi\|194429160, gi... - gi\|75209607\|ref\|ZP_00709825.1\| COG0083: Homoserine kinase [Escherichia coli B171], gi\|194429160\|ref\|... KHSE_SHIDS - Homoserine kinase OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=thrB PE=3 SV=1 KHSE_SHIBS - Homoserine kinase OS=Shigella boydii serotype 4 (strain Sb227) GN=thrB PE=3 SV=1 gi\|75256315, gi\|... - gi\|75256315\|ref\|ZP_00727987.1\| COG0083: Homoserine kinase [Escherichia coli E22], gi\|193065645\|ref\|Z... gi\|251783567, gi... - gi\|251783567\|ref\|YP_002997871.1\| hypothetical protein B21_00003 [Escherichia coli BL21], gi\|24237584... gi\|75515595, gi\|... - gi\|75515595\|ref\|ZP_00737752.1\| COG0083: Homoserine kinase [Escherichia coli 53638], gi\|188492615\|ref... gi\|226902053, gi... - gi\|237704141\|ref\|ZP_04534622.1\| homoserine kinase [Escherichia sp. 3_2_53FAA], gi\|226902053\|gb\|EEH88... gi\|253972025, gi... - gi\|254160126\|ref\|YP_003043232.1\| homoserine kinase [Escherichia coli B str. REL606], gi\|253972025\|gb... gi\|254286930, gi... - gi\|254286930\|ref\|YP_003052676.1\| homoserine kinase [Escherichia coli BL21(DE3)], gi\|253976235\|gb\|ACT...	1.0E-72	[1..308]	[1..308]
KHSE_ECOL6 - Homoserine kinase OS=Escherichia coli O6 GN=thrB PE=3 SV=1 KHSE_ECOL6 - Homoserine kinase OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=thrB PE=3 SV=1 gi\|227837932, gi... - gi\|227885103\|ref\|ZP_04002908.1\| homoserine kinase [Escherichia coli 83972], gi\|227837932\|gb\|EEJ48398...	1.0E-72	[1..308]	[1..308]
gi\|190906586, gi... - gi\|75239532\|ref\|ZP_00723502.1\| COG0083: Homoserine kinase [Escherichia coli F11], gi\|191173201\|ref\|Z... KHSE_ECOL5 - Homoserine kinase OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=thrB PE=3 SV=1	1.0E-72	[1..308]	[1..308]
KHSE_ECOLI - Homoserine kinase (EC 2.7.1.39) (HSK) (HK) - Escherichia coli EG10999 - homoserine kinase / Homoserine kinase KHSE_ECOBW - Homoserine kinase OS=Escherichia coli (strain K12 / MC4100 / BW2952) GN=thrB PE=3 SV=1 EG10999 - homoserine kinase / Homoserine kinase gi\|89106887, gi\|... - gi\|89106887\|ref\|AP_000667.1\| homoserine kinase [Escherichia coli str. K-12 substr. W3110], gi\|856742... gi\|83585311, gi\|... - gi\|83585311\|ref\|ZP_00923959.1\| COG0083: Homoserine kinase [Escherichia coli 101-1], gi\|194439274\|ref... KHSE_ECODH - Homoserine kinase OS=Escherichia coli (strain K12 / DH10B) GN=thrB PE=3 SV=1	2.0E-72	[1..308]	[1..308]
gi\|30061574, gi\|... - gi\|30061574\|ref\|NP_835745.1\| homoserine kinase [Shigella flexneri 2a str. 2457T], gi\|30039816\|gb\|AAP... gi\|24111453, gi\|... - gi\|24111453\|ref\|NP_705963.1\| homoserine kinase [Shigella flexneri 2a str. 301], gi\|24050201\|gb\|AAN41... KHSE_SHIFL - Homoserine kinase OS=Shigella flexneri GN=thrB PE=3 SV=1 KHSE_SHIF8 - Homoserine kinase OS=Shigella flexneri serotype 5b (strain 8401) GN=thrB PE=3 SV=1	2.0E-72	[1..308]	[1..308]
KHSE_SERMA - Homoserine kinase OS=Serratia marcescens GN=thrB PE=3 SV=1	3.0E-72	[1..309]	[1..309]
KHSE_PECAS - Homoserine kinase OS=Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) GN=thrB PE=3 SV=1 KHSE_ERWCT - Homoserine kinase OS=Erwinia carotovora subsp. atroseptica GN=thrB PE=3 SV=1	4.0E-72	[1..309]	[1..309]
KHSE_SHISS - Homoserine kinase OS=Shigella sonnei (strain Ss046) GN=thrB PE=3 SV=1	7.0E-72	[1..308]	[1..308]
gi\|77976165 - gi\|77976165\|ref\|ZP_00831698.1\| COG0083: Homoserine kinase [Yersinia frederiksenii ATCC 33641]	1.0E-71	[1..309]	[8..316]

Back

Predicted Domain #1

Region A:
Residues: [1-309]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVKVYAPASS ANMSVGFDVL GAAVTPVDGT LLGDVVSVEA ADHFRLHNLG RFADKLPPEP  60
   61 RENIVYQCWE RFCQALGKTI PVAMTLEKNM PIGSGLGSSA CSVVAALVAM NEHCGKPLND 120
  121 TRLLALMGEL EGRISGSIHY DNVAPCFLGG MQLMIEENGI ISQQVPGFDE WLWVLAYPGI 180
  181 KVSTAEARAI LPAQYRRQDC IAHGRHLAGF IHACYSRQPQ LAAALMKDVI AEPYRARLLP 240
  241 GFSQARQAVS EIGALASGIS GSGPTLFALC DKPETAQRVA DWLSKHYLQN QEGFVHICRL 300
  301 DTAGARVVG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	42.39794
Match:	1fwkA
Description:	Homoserine kinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
homoserine kinase activity	2.13523123963453	bayes_pls_golite062009
catalytic activity	1.20658247466773	bayes_pls_golite062009
amino acid kinase activity	0.292543190343241	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: