YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|213583481
Organism:	Salmonella enterica subsp. enterica serovar Typhi str. E98-0664
Length:	346 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|213583481.

Description	E-value	Query Range	Subject Range
BIOB_SHIB3 - Biotin synthase OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) GN=bioB PE=3 SV=1 BIOB_SHIBS - Biotin synthase OS=Shigella boydii serotype 4 (strain Sb227) GN=bioB PE=3 SV=1	2.0E-86	[1..346]	[1..346]
gi\|12620127 - gi\|12620127\|gb\|AAG60579.1\|AF250776_3 biotin synthase BioB [uncultured bacterium pCosHE2]	2.0E-86	[1..346]	[1..346]
gi\|167550532, gi... - gi\|205324625\|gb\|EDZ12464.1\| biotin synthase [Salmonella enterica subsp. enterica serovar Saintpaul s... BIOB_SALPB - Biotin synthase OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=bioB PE=3 SV=1 BIOB_SALTY - Biotin synthase OS=Salmonella typhimurium GN=bioB PE=3 SV=2 BIOB_SALPC - Biotin synthase OS=Salmonella paratyphi C (strain RKS4594) GN=bioB PE=3 SV=1 BIOB_SALPB - Biotin synthase OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=bioB PE=3 SV=1 gi\|195630936, gi... - gi\|195630936\|gb\|EDX49522.1\| biotin synthase [Salmonella enterica subsp. enterica serovar Newport str... gi\|205327729, gi... - gi\|205327729\|gb\|EDZ14493.1\| biotin synthase [Salmonella enterica subsp. enterica serovar 4,[5],12:i:... BIOB_SALTY - Biotin synthase OS=Salmonella typhimurium GN=bioB PE=3 SV=2 lcl\|NC_016856.1_... - [gene=bioB] [protein=biotin synthetase] [protein_id=YP_005236513.1] [location=860511..861551] BIOB_SALTY - Biotin synthase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=bioB PE=3 SV=2 gi\|197264303, gi... - gi\|197264303\|ref\|ZP_03164377.1\| biotin synthase [Salmonella enterica subsp. enterica serovar Saintpa... BIOB_SALNS - Biotin synthase OS=Salmonella newport (strain SL254) GN=bioB PE=3 SV=1	3.0E-86	[1..346]	[1..346]
BIOB_SALEP - Biotin synthase OS=Salmonella enteritidis PT4 (strain P125109) GN=bioB PE=3 SV=1 gi\|204320930, gi... - gi\|204929936\|ref\|ZP_03220957.1\| biotin synthase [Salmonella enterica subsp. enterica serovar Javiana... gi\|199601851, gi... - gi\|200389406\|ref\|ZP_03216017.1\| biotin synthase [Salmonella enterica subsp. enterica serovar Virchow... BIOB_SALDC - Biotin synthase OS=Salmonella dublin (strain CT_02021853) GN=bioB PE=3 SV=1 BIOB_SALPK - Biotin synthase OS=Salmonella paratyphi A (strain AKU_12601) GN=bioB PE=3 SV=1 BIOB_SALSV - Biotin synthase OS=Salmonella schwarzengrund (strain CVM19633) GN=bioB PE=3 SV=1 gi\|194456907, gi... - gi\|194470543\|ref\|ZP_03076527.1\| biotin synthase [Salmonella enterica subsp. enterica serovar Kentuck... BIOB_SALHS - Biotin synthase OS=Salmonella heidelberg (strain SL476) GN=bioB PE=3 SV=1 gi\|168820067, gi... - gi\|205343171\|gb\|EDZ29935.1\| biotin synthase [Salmonella enterica subsp. enterica serovar Weltevreden... gi\|168263711, gi... - gi\|205347752\|gb\|EDZ34383.1\| biotin synthase [Salmonella enterica subsp. enterica serovar Hadar str. ... gi\|205340434, gi... - gi\|205340434\|gb\|EDZ27198.1\| biotin synthase [Salmonella enterica subsp. enterica serovar Heidelberg ... gi\|197290189, gi... - gi\|197290189\|gb\|EDY29546.1\| biotin synthase [Salmonella enterica subsp. enterica serovar Schwarzengr... gi\|168230678, gi... - gi\|205334802\|gb\|EDZ21566.1\| biotin synthase [Salmonella enterica subsp. enterica serovar Kentucky st... BIOB_SALPA - Biotin synthase OS=Salmonella paratyphi A (strain ATCC 9150 / SARB42) GN=bioB PE=3 SV=1 BIOB_SALPA - Biotin synthase OS=Salmonella paratyphi A GN=bioB PE=3 SV=1	3.0E-86	[1..346]	[1..346]
gi\|124532404, gi... - gi\|124532404\|ref\|ZP_01702230.1\| biotin synthase [Escherichia coli B], gi\|124498032\|gb\|EAY45566.1\| bi... BIOB_ECO8A - Biotin synthase OS=Escherichia coli O8 (strain IAI1) GN=bioB PE=3 SV=1 BIOB_ECO27 - Biotin synthase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=bioB PE=3 SV=1 BIOB_ECO7I - Biotin synthase OS=Escherichia coli O7:K1 (strain IAI39 / ExPEC) GN=bioB PE=3 SV=1 BIOB_ECO55 - Biotin synthase OS=Escherichia coli (strain 55989 / EAEC) GN=bioB PE=3 SV=1 gi\|195182795 - gi\|195182795\|dbj\|BAG66375.1\| biotin synthetase [Escherichia coli O111:H-] BIOB_ECOLU - Biotin synthase OS=Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC) GN=bioB PE=3 SV=1 gi\|89107626, gi\|... - gi\|89107626\|ref\|AP_001406.1\| biotin synthase [Escherichia coli str. K-12 substr. W3110], gi\|85674758... gi\|194411959, gi... - gi\|75208775\|ref\|ZP_00709064.1\| COG0502: Biotin synthase and related enzymes [Escherichia coli B171],... sp\|B7ULX2\|BIOB_ECO27 - Biotin synthase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=bioB PE=3 SV=1 gi\|75228359, gi\|... - gi\|75228359\|ref\|ZP_00715007.1\| COG0502: Biotin synthase and related enzymes [Escherichia coli B7A], ... BIOB_ECO24 - Biotin synthase OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=bioB PE=3 SV=1 BIOB_ECOHS - Biotin synthase OS=Escherichia coli O9:H4 (strain HS) GN=bioB PE=3 SV=1 gi\|188494744, gi... - gi\|75511378\|ref\|ZP_00734063.1\| COG0502: Biotin synthase and related enzymes [Escherichia coli 53638]... BIOB_SHISS - Biotin synthase OS=Shigella sonnei (strain Ss046) GN=bioB PE=3 SV=1 gi\|75235853 - gi\|75235853\|ref\|ZP_00720008.1\| COG0502: Biotin synthase and related enzymes [Escherichia coli E11001... gi\|75255326, gi\|... - gi\|75255326\|ref\|ZP_00727155.1\| COG0502: Biotin synthase and related enzymes [Escherichia coli E22], ... gi\|194439770, gi... - gi\|83584841\|ref\|ZP_00923500.1\| COG0502: Biotin synthase and related enzymes [Escherichia coli 101-1]... EG10118 - biotin synthase / Biotin synthase; dethiobiotin to biotin pathway; iron-sulfur enzyme BIOB_ECOLC - Biotin synthase OS=Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) GN=bioB PE=3 SV=1 gi\|238860093, gi... - gi\|238900033\|ref\|YP_002925829.1\| biotin synthase [Escherichia coli BW2952], gi\|238860093\|gb\|ACR62091... gi\|251784294, gi... - gi\|251784294\|ref\|YP_002998598.1\| hypothetical protein B21_00759 [Escherichia coli BL21], gi\|24237656... BIOB_ECOSM - Biotin synthase OS=Escherichia coli (strain SMS-3-5 / SECEC) GN=bioB PE=3 SV=1 gi\|254287666, gi... - gi\|254287666\|ref\|YP_003053414.1\| biotin synthase [Escherichia coli BL21(DE3)], gi\|253976973\|gb\|ACT42... BIOB_ECODH - Biotin synthase OS=Escherichia coli (strain K12 / DH10B) GN=bioB PE=3 SV=1 gi\|253972753, gi... - gi\|254160852\|ref\|YP_003043960.1\| biotin synthase [Escherichia coli B str. REL606], gi\|253972753\|gb\|A... EG10118 - biotin synthase / Biotin synthase; dethiobiotin to biotin pathway; iron-sulfur enzyme BIOB_ECOLI - Biotin synthase (EC 2.8.1.6) (Biotin synthetase) - Escherichia coli	3.0E-86	[1..346]	[1..346]
gi\|25294055 - pir\|\|F85585 biotin synthesis, sulfur insertion [imported] - Escherichia coli (strain O157:H7, substr... gi\|12513761, gi\|... - gi\|15800526\|ref\|NP_286538.1\| biotin synthase [Escherichia coli O157:H7 EDL933], gi\|12513761\|gb\|AAG55...	3.0E-86	[1..346]	[1..346]
BIOB_ECOL6 - Biotin synthase OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=bioB PE=3 SV=1 BIOB_ECO45 - Biotin synthase OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=bioB PE=3 SV=1 BIOB_ECO81 - Biotin synthase OS=Escherichia coli O81 (strain ED1a) GN=bioB PE=3 SV=1 BIOB_ECOL6 - Biotin synthase OS=Escherichia coli O6 GN=bioB PE=3 SV=1 gi\|237707269, gi... - gi\|237707269\|ref\|ZP_04537750.1\| biotin synthase [Escherichia sp. 3_2_53FAA], gi\|226898479\|gb\|EEH8473... gi\|227839015, gi... - gi\|227884263\|ref\|ZP_04002068.1\| biotin synthase [Escherichia coli 83972], gi\|227839015\|gb\|EEJ49481.1... BIOB_ECOK1 - Biotin synthase OS=Escherichia coli O1:K1 / APEC GN=bioB PE=3 SV=1 BIOB_ECOUT - Biotin synthase OS=Escherichia coli (strain UTI89 / UPEC) GN=bioB PE=3 SV=1	3.0E-86	[1..346]	[1..346]
gi\|208808075, gi... - gi\|208808075\|ref\|ZP_03250412.1\| biotin synthase [Escherichia coli O157:H7 str. EC4206], gi\|208727876... gi\|195936813 - gi\|195936813\|ref\|ZP_03082195.1\| biotin synthase [Escherichia coli O157:H7 str. EC4024] gi\|168786986, gi... - gi\|189373194\|gb\|EDU91610.1\| biotin synthase [Escherichia coli O157:H7 str. EC869], gi\|168786986\|ref\|... gi\|168779316, gi... - gi\|189002816\|gb\|EDU71802.1\| biotin synthase [Escherichia coli O157:H7 str. EC4076], gi\|168779316\|ref... gi\|217322605, gi... - gi\|217326384\|ref\|ZP_03442468.1\| biotin synthase [Escherichia coli O157:H7 str. TW14588], gi\|21732260... BIOB_ECO5E - Biotin synthase OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=bioB PE=3 SV=1 gi\|208822295, gi... - gi\|208822295\|ref\|ZP_03262614.1\| biotin synthase [Escherichia coli O157:H7 str. EC4042], gi\|208737780... gi\|208815801, gi... - gi\|208815801\|ref\|ZP_03256980.1\| biotin synthase [Escherichia coli O157:H7 str. EC4045], gi\|208732449... gi\|168776427, gi... - gi\|187768146\|gb\|EDU31990.1\| biotin synthase [Escherichia coli O157:H7 str. EC4196], gi\|168776427\|ref... gi\|168763417, gi... - gi\|189366479\|gb\|EDU84895.1\| biotin synthase [Escherichia coli O157:H7 str. EC4501], gi\|168763417\|ref... gi\|168757116, gi... - gi\|189355846\|gb\|EDU74265.1\| biotin synthase [Escherichia coli O157:H7 str. EC4401], gi\|168757116\|ref... gi\|168750320, gi... - gi\|188015512\|gb\|EDU53634.1\| biotin synthase [Escherichia coli O157:H7 str. EC4113], gi\|168750320\|ref... gi\|254591369, gi... - gi\|254791969\|ref\|YP_003076806.1\| biotin synthase [Escherichia coli O157:H7 str. TW14359], gi\|2545913... gi\|15830107, gi\|... - gi\|15830107\|ref\|NP_308880.1\| biotin synthase [Escherichia coli O157:H7 str. Sakai], gi\|13360312\|dbj\|... gi\|209776122, gi... - pir\|\|E90735 biotin synthetase [imported] - Escherichia coli (strain O157:H7, substrain RIMD 0509952)... BIOB_ECO57 - Biotin synthase OS=Escherichia coli O157:H7 GN=bioB PE=3 SV=3	4.0E-86	[1..346]	[1..346]
BIOB_SALCH - Biotin synthase OS=Salmonella choleraesuis GN=bioB PE=3 SV=1 BIOB_SALCH - Biotin synthase OS=Salmonella choleraesuis (strain SC-B67) GN=bioB PE=3 SV=1	5.0E-86	[1..346]	[1..346]
gi\|190905542, gi... - gi\|75237111\|ref\|ZP_00721165.1\| COG0502: Biotin synthase and related enzymes [Escherichia coli F11], ... BIOB_ECOL5 - Biotin synthase OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=bioB PE=3 SV=1	7.0E-86	[1..346]	[1..346]

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Predicted Domain #1

Region A:
Residues: [1-346]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MARHPRWTLS QVTELFEKPL LELLFEAQQI HRQHFDPQQV QVSTLLSIKT GACPEDCKYC  60
   61 PQSSRYKTGL EAERLMEVEQ VLDSARKAKN AGSTRFCMGA AWKNPHERDM PYLEKIVQGV 120
  121 KAMGLETCMT LGMLNESQAQ RLANAGLDYY NHNLDTSPEF YGNIITTRTY QERLDTLEKV 180
  181 REAGIKVCSG GIVGLGETVT DRAGLLLQLA NLPTPPESVP INMLVKVKGT PLADNDDVDA 240
  241 FDFIRTIAVA RIMMPTSYVR LSAGREQMNE QTQAMCFMAG ANSIFYGCKL LTTPNPAEDK 300
  301 DLQLFRKLGL NPQQTRVLAG DNEQQQRLEQ TLMTPDTDDY YNAAAL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	87.39794
Match:	1r30A
Description:	The Crystal Structure of Biotin Synthase, an S-Adenosylmethionine-Dependent Radical Enzyme
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
biotin synthase activity	4.96431653338581	bayes_pls_golite062009
radical SAM enzyme activity	4.81217611621334	bayes_pls_golite062009
sulfurtransferase activity	3.43375708969779	bayes_pls_golite062009
transferase activity, transferring sulfur-containing groups	2.79703059227143	bayes_pls_golite062009
coproporphyrinogen oxidase activity	1.98937742831419	bayes_pls_golite062009
catalytic activity	1.48331922124015	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor	1.37188743230327	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors	1.18901545014659	bayes_pls_golite062009
oxidoreductase activity	0.593156857804038	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: