YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|166010415, gi...
Organism:	Yersinia pestis biovar Antiqua str. E1979001
Length:	450 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|166010415, gi....

Description	E-value	Query Range	Subject Range
gi\|45440000, gi\|... - gi\|45440000\|ref\|NP_991539.1\| osmolarity sensor protein [Yersinia pestis biovar Microtus str. 91001],...	9.0E-71	[1..450]	[1..450]
gi\|152959614, gi... - gi\|77631119\|ref\|ZP_00793705.1\| COG0642: Signal transduction histidine kinase [Yersinia pseudotubercu...	3.0E-70	[1..450]	[1..450]
gi\|77975054 - gi\|77975054\|ref\|ZP_00830591.1\| COG0642: Signal transduction histidine kinase [Yersinia frederiksenii...	1.0E-68	[1..449]	[1..449]
gi\|77978700 - gi\|77978700\|ref\|ZP_00834126.1\| COG0642: Signal transduction histidine kinase [Yersinia intermedia AT...	8.0E-68	[1..449]	[1..449]
gi\|77962673 - gi\|77962673\|ref\|ZP_00826490.1\| COG0642: Signal transduction histidine kinase [Yersinia mollaretii AT...	7.0E-67	[1..437]	[1..437]
gi\|77958304 - gi\|77958304\|ref\|ZP_00822340.1\| COG0642: Signal transduction histidine kinase [Yersinia bercovieri AT...	1.0E-66	[1..437]	[1..437]
gi\|3402275 - gi\|3402275\|emb\|CAA70147.1\| EnvZ protein [Yersinia enterocolitica]	1.0E-66	[1..450]	[1..450]
gi\|85060296, gi\|... - gi\|85060296\|ref\|YP_455998.1\| osmolarity sensor protein [Sodalis glossinidius str. 'morsitans'], gi\|8...	5.0E-66	[1..450]	[1..450]
gi\|79091, gi\|47665 - pir\|\|S01367 inner membrane protein envZ - Salmonella typhimurium, gi\|47665\|emb\|CAA30935.1\| unnamed p... gi\|47665\|emb\|CAA... - unnamed protein product [Salmonella typhimurium]	5.0E-66	[1..441]	[1..441]
gi\|26110433, gi\|... - gi\|26250004\|ref\|NP_756044.1\| osmolarity sensor protein [Escherichia coli CFT073], gi\|26110433\|gb\|AAN... gi\|91212878, gi\|... - gi\|91212878\|ref\|YP_542864.1\| osmolarity sensor protein [Escherichia coli UTI89], gi\|91074452\|gb\|ABE0... gi\|115514795, gi... - gi\|117625671\|ref\|YP_858994.1\| osmolarity sensor protein [Escherichia coli APEC O1], gi\|115514795\|gb\|... gi\|218367231, gi... - gi\|218560462\|ref\|YP_002393375.1\| osmolarity sensor protein [Escherichia coli S88], gi\|218367231\|emb\|... gi\|226902398, gi... - gi\|237703134\|ref\|ZP_04533615.1\| osmolarity sensor protein envZ [Escherichia sp. 3_2_53FAA], gi\|22690... gi\|170518903, gi... - gi\|170681185\|ref\|YP_001745652.1\| osmolarity sensor protein EnvZ [Escherichia coli SMS-3-5], gi\|17051... gi\|215266757, gi... - gi\|215488685\|ref\|YP_002331116.1\| osmolarity sensor protein [Escherichia coli O127:H6 str. E2348/69],... gi\|227883538, gi... - gi\|227883538\|ref\|ZP_04001343.1\| sensory histidine kinase in two-component regulatory system with Omp...	5.0E-66	[1..444]	[1..444]

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Predicted Domain #1

Region A:
Residues: [1-128]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKWWRFSPRS SFARTLLLIV TLLFVSLVTT YLVVLNFAIL PSLQQFNKVL AYEVRMLMTD  60
   61 RLQLEDGTLL EVPPAFRREI YRELGISLYT NAAAEESGLR WAQHYKFLSD QMAQQLGGPT 120
  121 DVRVEVNK

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.868	d.68.3	SirA-like

Predicted Domain #2

Region A:
Residues: [129-292]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSPVVWLKTW LSPDIWVRVP LTEIHQGDFS PLFRYTLAIM LLAVGGAWLF IRIQNRPLVE  60
   61 LEHAALQVGK GNIPPPLREY GASEVRSVTR AFNQMAAGVK LLSDDRTLLM AGVSHDLRTP 120
  121 LTRIRLATEM MSEDDAYLSE SINKDIEECN AIIEQFIDYL RTGQ

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	2.31
Match:	2f95B
Description:	M intermediate structure of sensory rhodopsin II/transducer complex in combination with the ground state structure
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [293-450]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EMPTEPSDLN SVLGEVIAAE SGYERVIETD LAEGEVLVDI HPLSIKRALT NMVVNAARYG  60
   61 NGWIKVSSGK ELQRAWFQVE DDGPGIKPED LKHLLQPFVR GDSARSTSGT GLGLAIVQRI 120
  121 IDAHAGSLEI GTSKRGGLRI RAYIPLPLDV KPKPPAVA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	27.522879
Match:	1bxdA
Description:	Histidine kinase domain of the osmosensor EnvZ
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein histidine kinase activity	4.82398483954378	bayes_pls_golite062009
two-component sensor activity	4.79766298875975	bayes_pls_golite062009
phosphotransferase activity, nitrogenous group as acceptor	4.76164614213074	bayes_pls_golite062009
protein kinase activity	3.57531862667106	bayes_pls_golite062009
kinase activity	3.47809160998617	bayes_pls_golite062009
two-component response regulator activity	3.47298917518553	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	3.36409984155553	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	3.20609336929586	bayes_pls_golite062009
signal transducer activity	2.91676094682887	bayes_pls_golite062009
molecular transducer activity	2.91676094682887	bayes_pls_golite062009
catalytic activity	2.4793446884777	bayes_pls_golite062009
transferase activity	2.46167639226183	bayes_pls_golite062009
binding	0.162154598845105	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: