YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|215411548
Organism:	Mycobacterium tuberculosis 94_M4241A
Length:	687 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|215411548.

Description	E-value	Query Range	Subject Range
gi\|41396047, gi\|... - gi\|41407694\|ref\|NP_960530.1\| hypothetical protein MAP1596 [Mycobacterium avium subsp. paratuberculos...	387.0	[0..1]	[673..1]
gi\|21225257, gi\|... - gi\|7649556\|emb\|CAB89031.1\| putative membrane transport protein. [Streptomyces coelicolor A3(2)], gi\|...	379.0	[0..5]	[667..10]
gi\|90196450, gi\|... - gi\|90204398\|ref\|ZP_01207041.1\| Drug resistance transporter EmrB/QacA subfamily [Mycobacterium vanbaa...	354.0	[0..1]	[677..1]
gi\|29832374, gi\|... - gi\|29832374\|ref\|NP_827008.1\| multidrug-efflux transporter [Streptomyces avermitilis MA-4680], gi\|296...	349.0	[0..2]	[650..9]
gi\|89341017, gi\|... - gi\|89341017\|ref\|ZP_01193263.1\| Drug resistance transporter EmrB/QacA subfamily [Mycobacterium flaves...	344.0	[0..3]	[680..35]
gi\|108770141, gi... - gi\|108799722\|ref\|YP_639919.1\| EmrB/QacA family drug resistance transporter [Mycobacterium sp. MCS], ... gi\|92912725, gi\|... - gi\|92912725\|ref\|ZP_01281355.1\| Drug resistance transporter EmrB/QacA subfamily [Mycobacterium sp. KM...	341.0	[0..15]	[670..13]
gi\|126435366, gi... - gi\|92907538\|ref\|ZP_01276318.1\| Drug resistance transporter EmrB/QacA subfamily [Mycobacterium sp. JL...	341.0	[0..15]	[670..13]
gi\|121637781, gi... - gi\|121637781\|ref\|YP_978004.1\| putative integral membrane protein [Mycobacterium bovis BCG str. Paste... gi\|224773378, gi... - gi\|224990265\|ref\|YP_002644952.1\| putative integral membrane protein [Mycobacterium bovis BCG str. To... gi\|31793068, gi\|... - gi\|31793068\|ref\|NP_855561.1\| hypothetical protein Mb1909 [Mycobacterium bovis AF2122/97], gi\|3161865...	330.0	[0..284]	[687..1]
gi\|54014576, gi\|... - gi\|54023068\|ref\|YP_117310.1\| putative transporter [Nocardia farcinica IFM 10152], gi\|54014576\|dbj\|BA...	284.0	[0..10]	[668..4]

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Predicted Domain #1

Region A:
Residues: [1-505]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAGPTAPTTA PTAIRAGGPL LSPVRRNIIF TALVFGVLVA ATGQTIVVPA LPTIVAELGS  60
   61 TVDQSWAVTS YLLGGTVVVV VAGKLGDLLG RNRVLLGSVV VFVVGSVLCG LSQTMTMLAI 120
  121 SRALQGVGAG AISVTAYALA AEVVPLRDRG RYQGVLGAVF GVNTVTGPLL GGWLTDYLSW 180
  181 RWAFWINVPV SIAVLTVAAT AVPALARPPK PVIDYLGILV IAVATTALIM ATSWGGTTYA 240
  241 WGSATIVGLL IGAAVALGFF VWLEGRAAAA ILPPRLFGSP VFAVCCVLSF VVGFAMLGAL 300
  301 TFVPIYLGYV DGASATASGL RTLPMVIGLL IASTGTGVLV GRTGRYKIFP VAGMALMAVA 360
  361 FLLMSQMDEW TPPLLQSLYL VVLGAGIGLS MQVLVLIVQN TSSFEDLGVA TSGVTFFRVV 420
  421 GASFGTATFG ALFVNFLDRR LGSALTSGAV PVPAVPSPAV LHQLPQSMAA PIVRAYAESL 480
  481 TQVFLCAVSV TVVGFILALL LREVP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	34.30103
Match:	1pw4A
Description:	Crystal Structure of the Glycerol-3-Phosphate Transporter from E.Coli
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transporter activity	4.09176719149278	bayes_pls_golite062009
substrate-specific transporter activity	3.59744164024479	bayes_pls_golite062009
transmembrane transporter activity	3.5865018981083	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	3.54194478414824	bayes_pls_golite062009
ion transmembrane transporter activity	2.21266150105753	bayes_pls_golite062009
organic acid transmembrane transporter activity	2.15783210522667	bayes_pls_golite062009
cation transmembrane transporter activity	1.79369588808394	bayes_pls_golite062009
active transmembrane transporter activity	1.59419818573076	bayes_pls_golite062009
secondary active transmembrane transporter activity	1.22264637452409	bayes_pls_golite062009
binding	1.01584233411372	bayes_pls_golite062009
polyol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
alcohol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
glycerol transmembrane transporter activity	0.812001619402678	bayes_pls_golite062009
symporter activity	0.74591237387473	bayes_pls_golite062009
solute:cation symporter activity	0.74591237387473	bayes_pls_golite062009
cation:sugar symporter activity	0.143419068761182	bayes_pls_golite062009
sugar:hydrogen symporter activity	0.143419068761182	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [506-687]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTDIHDDADD LGDGFGVPRA ESPEDVLEIA VRRMLPNGVR LRDIATQPGC GLGVAELWAL  60
   61 LRIYQYQRLF EAVRLTDIGR HLHVPYQVFE PVFDRLVQTG YAARDGDILT LTPSGHRQVD 120
  121 SLAVLIRQWL LDHLAVAPGL KRQPDHQFEA ALQHVTDAVL VQRDWYEDLG DLSESRQLAA 180
  181 TT

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	2.06
Match:	2h09A
Description:	No description for 2h09A was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: