YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|161486427
Organism:	Shigella flexneri 2a str. 2457T
Length:	282 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|161486427.

Description	E-value	Query Range	Subject Range
gi\|26110188, gi\|... - gi\|26249760\|ref\|NP_755800.1\| Dihydropteroate synthase [Escherichia coli CFT073], gi\|26110188\|gb\|AAN8...	368.0	[0..1]	[282..23]
gi\|237706072, gi... - gi\|237706072\|ref\|ZP_04536553.1\| 7,8-dihydropteroate synthase [Escherichia sp. 3_2_53FAA], gi\|2268991... gi\|91074172, gi\|... - gi\|91212598\|ref\|YP_542584.1\| 7,8-dihydropteroate synthase [Escherichia coli UTI89], gi\|91074172\|gb\|A...	367.0	[0..1]	[282..23]
gi\|74313714, gi\|... - gi\|74313714\|ref\|YP_312133.1\| 7,8-dihydropteroate synthase [Shigella sonnei Ss046], gi\|73857191\|gb\|AA...	367.0	[0..1]	[282..16]
gi\|162138365 - gi\|162138365\|ref\|YP_542584.2\| dihydropteroate synthase [Escherichia coli UTI89] gi\|218367016, gi... - gi\|218560247\|ref\|YP_002393160.1\| dihydropteroate synthase [Escherichia coli S88], gi\|218367016\|emb\|C... gi\|117625471, gi... - gi\|117625471\|ref\|YP_858794.1\| dihydropteroate synthase [Escherichia coli APEC O1], gi\|115514595\|gb\|A...	367.0	[0..1]	[282..1]
gi\|81246996, gi\|... - gi\|82545585\|ref\|YP_409532.1\| 7,8-dihydropteroate synthase [Shigella boydii Sb227], gi\|81246996\|gb\|AB...	367.0	[0..1]	[282..16]
gi\|606115\|gb\|AAA... - dihydropteroate synthase [Escherichia coli] gi\|13363529 - gi\|13363529\|dbj\|BAB37479.1\| 7,8-dihydropteroate synthase [Escherichia coli O157:H7 str. Sakai] gi\|56480281, gi\|... - gi\|56480281\|ref\|NP_708976.2\| 7,8-dihydropteroate synthase [Shigella flexneri 2a str. 301], gi\|563838... gi\|209758270, gi... - gi\|606115\|gb\|AAA57978.1\| dihydropteroate synthase [Escherichia coli], pir\|\|C85981 7,8-dihydropteroat... gi\|30042774, gi\|... - gi\|30064515\|ref\|NP_838686.1\| 7,8-dihydropteroate synthase [Shigella flexneri 2a str. 2457T], gi\|3004... gi\|13363529 - gi\|13363529\|dbj\|BAB37479.1\| 7,8-dihydropteroate synthase [Escherichia coli O157:H7] gi\|15803717, gi\|... - gi\|15803717\|ref\|NP_289751.1\| 7,8-dihydropteroate synthase [Escherichia coli O157:H7 EDL933], gi\|1251... gi\|49176323, gi\|... - gi\|49176323\|ref\|NP_417644.3\| 7,8-dihydropteroate synthase [Escherichia coli K12], gb\|AAC76209.1\| 7,8...	366.0	[0..1]	[282..16]
gi\|193061963, gi... - gi\|75260105\|ref\|ZP_00731383.1\| COG0294: Dihydropteroate synthase and related enzymes [Escherichia co... gi\|75208501, gi\|... - gi\|75208501\|ref\|ZP_00708821.1\| COG0294: Dihydropteroate synthase and related enzymes [Escherichia co...	365.0	[0..1]	[282..1]
gi\|746402 - gi\|746402\|gb\|AAA97509.1\| dihydropteroate synthase	363.0	[0..1]	[282..1]
gi\|82778491, gi\|... - gi\|82778491\|ref\|YP_404840.1\| 7,8-dihydropteroate synthase [Shigella dysenteriae Sd197], gi\|81242639\|...	362.0	[0..1]	[282..16]

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Predicted Domain #1

Region A:
Residues: [1-282]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLFAQGTSL DLSHPHVMGI LNVTPDSFSD GGTHNSLIDA VKHANLMINA GATIIDVGGE  60
   61 STRPGAAEVS VEEELQRVIP VVEAIAQRFE VWISVDTSKP EVIRESAKVG AHIINDIRSL 120
  121 SEPGALEAAA ETGLPVCLMH MQGNPKTMQE APKYDDVFAE VNRYFIEQIA RCEQAGIAKE 180
  181 KLLLDPGFGF GKNLSHNYSL LARLAEFHHF NLPLLVGMSR KSMIGQLLNV GPSERLSGSL 240
  241 ACAVIAAMQG AHIIRVHDVK ETVEAMRVVE ATLSAKENKR YE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	102.0
Match:	1aj0A
Description:	CRYSTAL STRUCTURE OF A TERNARY COMPLEX OF E. COLI DIHYDROPTEROATE SYNTHASE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
dihydropteroate synthase activity	5.55484533231129	bayes_pls_golite062009
catalytic activity	1.94758748334979	bayes_pls_golite062009
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity	1.59882258515727	bayes_pls_golite062009
transferase activity	1.09979615331123	bayes_pls_golite062009
transferase activity, transferring alkyl or aryl (other than methyl) groups	1.09502814971491	bayes_pls_golite062009
binding	0.691846952184196	bayes_pls_golite062009
dihydroneopterin aldolase activity	0.570043482286316	bayes_pls_golite062009
diphosphotransferase activity	0.246882532482481	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: