YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|166213239, gi...
Organism:	Yersinia pestis biovar Antiqua str. B42003004
Length:	470 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|166213239, gi....

Description	E-value	Query Range	Subject Range
gi\|229706429, gi... - gi\|229836361\|ref\|ZP_04456528.1\| siroheme synthase / precorrin-2 oxidase /sirohydrochlorin ferrochela... gi\|21960942, gi\|... - gi\|22127811\|ref\|NP_671234.1\| uroporphyrinogen III methylase [Yersinia pestis KIM], gi\|21960942\|gb\|AA...	0.0	[1..470]	[13..482]
CYSG2_YERPS - Siroheme synthase 2 OS=Yersinia pseudotuberculosis GN=cysG2 PE=3 SV=1 CYSG2_YERPS - Siroheme synthase 2 OS=Yersinia pseudotuberculosis serotype I (strain IP32953) GN=cysG2 PE=3 SV=1 gi\|170022493, gi... - gi\|170022493\|ref\|YP_001718998.1\| siroheme synthase [Yersinia pseudotuberculosis YPIII], gi\|169749027... CYSG2_YERP3 - Siroheme synthase 2 OS=Yersinia pseudotuberculosis serotype O:1b (strain IP 31758) GN=cysG2 PE=3 SV=...	0.0	[1..470]	[1..473]
gi\|77975034, gi\|... - gi\|77975034\|ref\|ZP_00830571.1\| COG0007: Uroporphyrinogen-III methylase [Yersinia frederiksenii ATCC ...	0.0	[1..470]	[1..472]
gi\|77962694, gi\|... - gi\|77962694\|ref\|ZP_00826511.1\| COG0007: Uroporphyrinogen-III methylase [Yersinia mollaretii ATCC 439...	0.0	[1..456]	[1..459]
CYSG_SHIB3 - Siroheme synthase OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) GN=cysG PE=3 SV=1 CYSG_SHIBS - Siroheme synthase OS=Shigella boydii serotype 4 (strain Sb227) GN=cysG PE=3 SV=1	0.0	[1..453]	[1..456]
CYSG_ECO24 - Siroheme synthase OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=cysG PE=3 SV=1 CYSG_ECOSE - Siroheme synthase OS=Escherichia coli (strain SE11) GN=cysG PE=3 SV=1 CYSG_ECO8A - Siroheme synthase OS=Escherichia coli O8 (strain IAI1) GN=cysG PE=3 SV=1	0.0	[1..453]	[1..456]
gi\|24053835, gi\|... - gi\|24114633\|ref\|NP_709143.1\| siroheme synthase [Shigella flexneri 2a str. 301], gi\|24053835\|gb\|AAN44... CYSG_SHIF8 - Siroheme synthase OS=Shigella flexneri serotype 5b (strain 8401) GN=cysG PE=3 SV=1 gi\|30065346, gi\|... - gi\|30065346\|ref\|NP_839517.1\| siroheme synthase [Shigella flexneri 2a str. 2457T], gi\|30043608\|gb\|AAP... CYSG_SHISS - Siroheme synthase OS=Shigella sonnei (strain Ss046) GN=cysG PE=3 SV=1 CYSG_SHIFL - Siroheme synthase OS=Shigella flexneri GN=cysG PE=3 SV=1	0.0	[1..453]	[1..456]
gi\|208726275, gi... - gi\|208806474\|ref\|ZP_03248811.1\| siroheme synthase [Escherichia coli O157:H7 str. EC4206], gi\|2087262... CYSG_ECOSM - Siroheme synthase OS=Escherichia coli (strain SMS-3-5 / SECEC) GN=cysG PE=3 SV=1 gi\|208739702, gi... - gi\|208819579\|ref\|ZP_03259899.1\| siroheme synthase [Escherichia coli O157:H7 str. EC4042], gi\|2087397... gi\|208733150, gi... - gi\|208811873\|ref\|ZP_03253202.1\| siroheme synthase [Escherichia coli O157:H7 str. EC4045], gi\|2087331... CYSG_ECO55 - Siroheme synthase OS=Escherichia coli (strain 55989 / EAEC) GN=cysG PE=3 SV=1 gi\|217320428, gi... - gi\|217324207\|ref\|ZP_03440291.1\| siroheme synthase [Escherichia coli O157:H7 str. TW14588], gi\|217320... gi\|193061862, gi... - gi\|75260342\|ref\|ZP_00731610.1\| COG0007: Uroporphyrinogen-III methylase [Escherichia coli E22], gi\|19... gi\|189369618, gi... - gi\|189369618\|gb\|EDU88034.1\| siroheme synthase [Escherichia coli O157:H7 str. EC4501], gi\|168759399\|r... gi\|85676672, gi\|... - gi\|89110641\|ref\|AP_004421.1\| fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase/... gi\|189359351, gi... - gi\|189359351\|gb\|EDU77770.1\| siroheme synthase [Escherichia coli O157:H7 str. EC4401], gi\|168753127\|r... gi\|187771618, gi... - gi\|187771618\|gb\|EDU35462.1\| siroheme synthase [Escherichia coli O157:H7 str. EC4196], gi\|168772734\|r... CYSG_ECOLC - Siroheme synthase OS=Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) GN=cysG PE=3 SV=1 gi\|168765722, gi... - gi\|189364751\|gb\|EDU83170.1\| siroheme synthase [Escherichia coli O157:H7 str. EC4486], gi\|168765722\|r... gi\|189374423, gi... - gi\|189374423\|gb\|EDU92839.1\| siroheme synthase [Escherichia coli O157:H7 str. EC869], gi\|168785179\|re... gi\|189002542, gi... - gi\|189002542\|gb\|EDU71528.1\| siroheme synthase [Escherichia coli O157:H7 str. EC4076], gi\|168779458\|r... CYSG_ECODH - Siroheme synthase OS=Escherichia coli (strain K12 / DH10B) GN=cysG PE=3 SV=1 gi\|168797146, gi... - gi\|189380160\|gb\|EDU98576.1\| siroheme synthase [Escherichia coli O157:H7 str. EC508], gi\|168797146\|re... gi\|194439502, gi... - gi\|83585121\|ref\|ZP_00923773.1\| COG0007: Uroporphyrinogen-III methylase [Escherichia coli 101-1], gi\|... CYSG_ECOHS - Siroheme synthase OS=Escherichia coli O9:H4 (strain HS) GN=cysG PE=3 SV=1 gi\|75211735, gi\|... - gi\|75211735\|ref\|ZP_00711799.1\| COG0007: Uroporphyrinogen-III methylase [Escherichia coli B171], gi\|1... gi\|191168412, gi... - gi\|75228409\|ref\|ZP_00715055.1\| COG0007: Uroporphyrinogen-III methylase [Escherichia coli B7A], gi\|19... CYSG_ECOBW - Siroheme synthase OS=Escherichia coli (strain K12 / MC4100 / BW2952) GN=cysG PE=3 SV=1 CYSG_ECO57 - Siroheme synthase OS=Escherichia coli O157:H7 GN=cysG PE=3 SV=1 gi\|242378894, gi... - gi\|251786621\|ref\|YP_003000925.1\| hypothetical protein B21_03171 [Escherichia coli BL21], gi\|24237889... gi\|253322849, gi... - gi\|254290046\|ref\|YP_003055794.1\| fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogen... gi\|12517996, gi\|... - gi\|15803881\|ref\|NP_289916.1\| siroheme synthase [Escherichia coli O157:H7 EDL933], gi\|12517996\|gb\|AAG... gi\|226839038, gi... - gi\|254038532\|ref\|ZP_04872588.1\| siroheme synthase [Escherichia sp. 1_1_43], gi\|226839038\|gb\|EEH71061... EG10188 - fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase /u... gi\|254163296, gi... - gi\|254163296\|ref\|YP_003046404.1\| fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogen... gi\|254594692, gi... - gi\|254795292\|ref\|YP_003080129.1\| fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogen... EG10188 - fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase /u... gi\|13363692, gi\|... - gi\|15833473\|ref\|NP_312246.1\| siroheme synthase [Escherichia coli O157:H7 str. Sakai], gi\|13363692\|db... CYSG_ECOLI - Siroheme synthase [Includes: Uroporphyrinogen-III C-methyltransferase (EC 2.1.1.107) (Urogen III met... gi\|168751811, gi... - gi\|188014206\|gb\|EDU52328.1\| siroheme synthase [Escherichia coli O157:H7 str. EC4113], gi\|168751811\|r...	0.0	[1..453]	[1..456]
CYSG_ECO45 - Siroheme synthase OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=cysG PE=3 SV=1 CYSG_ECOK1 - Siroheme synthase OS=Escherichia coli O1:K1 / APEC GN=cysG PE=3 SV=1 CYSG_ECOUT - Siroheme synthase OS=Escherichia coli (strain UTI89 / UPEC) GN=cysG PE=3 SV=1 gi\|226902365, gi... - gi\|237703101\|ref\|ZP_04533582.1\| siroheme synthase [Escherichia sp. 3_2_53FAA], gi\|226902365\|gb\|EEH88...	0.0	[1..453]	[1..456]
gi\|77958283, gi\|... - gi\|77958283\|ref\|ZP_00822319.1\| COG0007: Uroporphyrinogen-III methylase [Yersinia bercovieri ATCC 439...	0.0	[1..470]	[1..472]

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Predicted Domain #1

Region A:
Residues: [1-470]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDYFPIFCQL QHKACLLVGG GEIAERKARL LLDAGALVTV NACEFTPQFH HWADQGQLSL  60
   61 ISGEFVPELL ADKWLVIAAT DQLSVNALVY QSANQQRIFC NVVDDPKRTS FIMPSIIDRS 120
  121 PIMIAVSSGG KAPVLARLLR EKLEALLPQH LGQLAGNLRQ RVKQHFTVMT ERRRFWEKLL 180
  181 THDRLAQSLA NNDHVQADQH VEQLFSAPLT DRGEVVLVGA GPGDAGLLTL KGLQQIQQAD 240
  241 VVVYDRLVSD EVMNLVRRDA ERIFVGKQSG HHCVPQEQIN QILLQQAQSG KRVVRLKGGD 300
  301 PFIFGRGGEE LEELAGYGIP FSVVPGITAA SGCSAYSGIP LTHRDHAQSV RLVTGHAKKE 360
  361 GQLDWANLAA EKQTLVFYMG LSQAGEIQQQ LIQHGMPATT QVALVENGTS RHQRVVSGEL 420
  421 SQLALLSQQV SSPSLIIVGS VVSLREKLNW FSSRHHDDQP KVTECVAHVG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	125.0
Match:	1pjqA
Description:	Structure and function of CysG, the multifunctional methyltransferase/dehydrogenase/ferrochelatase for siroheme synthesis
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
uroporphyrin-III C-methyltransferase activity	3.70810184740502	bayes_pls_golite062009
C-methyltransferase activity	3.49766011792986	bayes_pls_golite062009
precorrin-2 dehydrogenase activity	2.67806035597297	bayes_pls_golite062009
sirohydrochlorin ferrochelatase activity	2.40719502419427	bayes_pls_golite062009
precorrin-4 C11-methyltransferase activity	2.23847861653053	bayes_pls_golite062009
catalytic activity	1.85393572319476	bayes_pls_golite062009
transferase activity	1.11319893632325	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	0.934144410066549	bayes_pls_golite062009
methyltransferase activity	0.915475179027344	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	0.637525028271766	bayes_pls_golite062009
ferrochelatase activity	0.15375007777431	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: