YRC Public Data Repository - Protein Structure Prediction

Protein:	PYRH_LACJO
Organism:	Lactobacillus johnsonii
Length:	241 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PYRH_LACJO.

Description	E-value	Query Range	Subject Range
gi\|23002919 - gi\|23002919\|ref\|ZP_00046591.1\| COG0528: Uridylate kinase [Lactobacillus gasseri] gi\|227094235, gi... - gi\|227521138\|ref\|ZP_03951187.1\| uridylate kinase [Lactobacillus gasseri JV-V03], gi\|227094235\|gb\|EEI... gi\|238834756, gi... - gi\|238852610\|ref\|ZP_04643020.1\| UMP kinase [Lactobacillus gasseri 202-4], gi\|238834756\|gb\|EEQ26983.1... PYRH_LACGA - Uridylate kinase OS=Lactobacillus gasseri (strain ATCC 33323 / DSM 20243 / JCM 1131 / NCIMB 11718 / ...	237.0	[0..1]	[241..1]
gi\|220708047, gi... - gi\|221088054\|ref\|ZP_03557588.1\| uridylate kinase [Geobacillus sp. Y412MC61], gi\|220708047\|gb\|EED6342... PYRH_GEOKA - Uridylate kinase OS=Geobacillus kaustophilus (strain HTA426) GN=pyrH PE=3 SV=1 gi\|229329603, gi... - gi\|229499545\|ref\|ZP_04393229.1\| uridylate kinase [Geobacillus sp. Y412MC52], gi\|229329603\|gb\|EEN9515... PYRH_GEOKA - Uridylate kinase OS=Geobacillus kaustophilus GN=pyrH PE=3 SV=1	232.0	[0..1]	[240..1]
PYRH_ENTFA - Uridylate kinase OS=Enterococcus faecalis (strain ATCC 700802 / V583) GN=pyrH PE=1 SV=1 PYRH_ENTFA - Uridylate kinase OS=Enterococcus faecalis GN=pyrH PE=1 SV=1	232.0	[0..1]	[240..1]
PYRH_LACSS - Uridylate kinase OS=Lactobacillus sakei subsp. sakei (strain 23K) GN=pyrH PE=3 SV=1	230.0	[0..1]	[241..1]
PYRH_LACDB - Uridylate kinase OS=Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC BAA-365) GN=pyrH PE=3 S... PYRH_LACDA - Uridylate kinase OS=Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081 / JCM...	229.0	[0..1]	[241..1]
PYRH_CARHZ - Uridylate kinase OS=Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901) GN=p...	229.0	[0..1]	[241..1]
PYRH_PEDPA - Uridylate kinase OS=Pediococcus pentosaceus (strain ATCC 25745 / 183-1w) GN=pyrH PE=3 SV=1	227.0	[0..1]	[241..1]
PYRH_LACS1 - Uridylate kinase OS=Lactobacillus salivarius (strain UCC118) GN=pyrH PE=3 SV=1	226.0	[0..1]	[240..1]
PYRH_LACPL - Uridylate kinase OS=Lactobacillus plantarum GN=pyrH PE=3 SV=1 PYRH_LACPL - Uridylate kinase OS=Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) GN=pyrH PE=3 ... gi\|254045809, gi... - gi\|254556882\|ref\|YP_003063299.1\| uridylate kinase [Lactobacillus plantarum JDM1], gi\|254045809\|gb\|AC... gi\|227894842, gi... - gi\|227894842\|ref\|ZP_04012647.1\| uridylate kinase [Lactobacillus plantarum subsp. plantarum ATCC 1491...	225.0	[0..1]	[240..1]
PYRH_LACRE - Uridylate kinase OS=Lactobacillus reuteri GN=pyrH PE=3 SV=1	225.0	[0..1]	[240..1]

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Predicted Domain #1

Region A:
Residues: [1-241]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQVKYKRII LKVSGEALAG EKGTGINPEV IKHLAEEIKS VHDMGVEIGI VCGGGNMWRG  60
   61 ETGANLGMER AQADYMGMLA TIMNGLALQD GLENLGVPTR VQTSIEMRQI AEPYIRRKAV 120
  121 RHLEKGRVVI FGGGTGNPYF STDTTAALRA AEINADVILM AKNGVDGVYS ADPKVDPNAK 180
  181 KYSELTQLDL ISKNLKVMDS TASSLSMDNN IPLVVFNVNK PGNIKKVVMG ENIGTVIKGD 240
  241 K

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	57.0
Match:	1z9dA
Description:	Crystal structure of a putative uridylate kinase (UMP-kinase) from Streptococcus pyogenes
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
kinase activity	5.43826659128409	bayes_pls_golite062009
nucleobase, nucleoside, nucleotide kinase activity	4.76215533422168	bayes_pls_golite062009
nucleotide kinase activity	4.36245911991838	bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor	4.17538459617947	bayes_pls_golite062009
uridylate kinase activity	3.54453921304057	bayes_pls_golite062009
catalytic activity	3.20382750184555	bayes_pls_golite062009
transferase activity	2.54481238004476	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.89315414622708	bayes_pls_golite062009
phosphotransferase activity, carboxyl group as acceptor	1.02979719559565	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: