YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|29726781
Organism:	Homo sapiens
Length:	416 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|29726781.

Description	E-value	Query Range	Subject Range
gi\|162319260 - gi\|162319260\|gb\|AAI56104.1\| DOT1-like, histone H3 methyltransferase (S. cerevisiae) [synthetic const... gi\|22001120, gi\|... - gi\|22094135\|ref\|NP_115871.1\| DOT1-like, histone H3 methyltransferase [Homo sapiens], gi\|22001120\|gb\|...	337.0	[0..1]	[416..1]
gi\|189442073 - gi\|189442073\|gb\|AAI67196.1\| DOT1-like, histone H3 methyltransferase (S. cerevisiae) [synthetic const... gi\|34582215, gi\|... - gi\|40556381\|ref\|NP_955354.1\| DOT1-like, histone H3 methyltransferase [Mus musculus], gi\|34582215\|gb\|...	328.0	[0..1]	[416..1]
gi\|109480178, gi... - gi\|109481477\|ref\|XP_001071372.1\| PREDICTED: similar to histone H3 methyltransferase DOT1 [Rattus nor...	324.0	[0..1]	[416..1]
gi\|76622383 - gi\|76622383\|ref\|XP_888334.1\| PREDICTED: similar to DOT1-like, histone H3 methyltransferase isoform 4...	309.0	[0..1]	[416..1]
gi\|47208951 - gi\|47208951\|emb\|CAF92242.1\| unnamed protein product [Tetraodon nigroviridis]	308.0	[0..17]	[416..36]
gi\|73987521 - gi\|73987521\|ref\|XP_542191.2\| PREDICTED: similar to Histone-lysine N-methyltransferase, H3 lysine-79 ...	308.0	[0..26]	[416..109]
gi\|68363004 - gi\|68363004\|ref\|XP_688431.1\| PREDICTED: similar to histone H3 methyltransferase DOT1 [Danio rerio]	307.0	[0..1]	[413..1]

Back

Predicted Domain #1

Region A:
Residues: [1-416]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGEKLELRLK SPVGAEPAVY PWPLPVYDKH HDAAHEIIET IRWVCEEIPD LKLAMENYVL  60
   61 IDYDTKSFES MQRLCDKYNR AIDSIHQLWK GTTQPMKLNT RPSTGLLRHI LQQVYNHSVT 120
  121 DPEKLNNYEP FSPEVYGETS FDLVAQMIDE IKMTDDDLFV DLGSGVGQVV LQVAAATNCK 180
  181 HHYGVEKADI PAKYAETMDR EFRKWMKWYG KKHAEYTLER GDFLSEEWRE RIANTSVIFV 240
  241 NNFAFGPEVD HQLKERFANM KEGGRIVSSK PFAPLNFRIN SRNLSDIGTI MRVVELSPLK 300
  301 GSVSWTGKPV SYYLHTIDRT ILENYFSSLK NPKLREEQEA ARRRQQRESK SNAATPTKGP 360
  361 EGKVAGPADA PMDSGAEEEK AGAATVKKPS PSKARKKKLN KKGRKMAGRK RGRPKK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	87.045757
Match:	1nw3A
Description:	Catalytic, N-terminal domain of histone methyltransferase Dot1l
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits