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View Structure Prediction Details

Protein: gi|28373840
Organism: Homo sapiens
Length: 159 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|28373840.

Description E-value Query
Range		 Subject
Range
IL10_HORSE - Interleukin-10 OS=Equus caballus GN=IL10 PE=2 SV=1
 197.0 [0..5] [152..25]
gi|73960666 - gi|73960666|ref|XP_851510.1| PREDICTED: similar to interleukin 20 precursor [Canis familiaris]
 195.0 [0..7] [153..30]
gi|114572230 - gi|114572230|ref|XP_001165088.1| PREDICTED: interleukin 19 isoform 1 [Pan troglodytes]
 193.0 [0..1] [159..57]
IL10_SAISC - Interleukin-10 OS=Saimiri sciureus GN=IL10 PE=2 SV=1
 192.0 [0..5] [152..25]
gi|15266466, gi|... - gi|15266466|gb|AAK91776.1| interleukin 19 [Homo sapiens], gi|119613928|gb|EAW93522.1| interleukin 19...
 191.0 [0..1] [159..57]
IL10_CALJA - Interleukin-10 OS=Callithrix jacchus GN=IL10 PE=2 SV=1
 191.0 [0..5] [152..25]
gi|83722853 - gi|83722853|gb|ABC41664.1| interleukin-10 [Oryctolagus cuniculus]
 191.0 [0..6] [152..26]
IL20_MOUSE - Interleukin-20 OS=Mus musculus GN=Il20 PE=2 SV=1
 190.0 [0..7] [153..30]
gi|61862982 - gi|61862982|ref|XP_593569.1| PREDICTED: similar to interleukin 20 [Bos taurus]
 190.0 [0..7] [151..30]

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Predicted Domain #1
Region A:
Residues: [1-159] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SVDNHGLRRC LISTDMHHIE ESFQEIKRAI QAKDTFPNVT ILSTLETLQI IKPLDVCCVT  60
   61 KNLLAFYVDR VFKDHQEPNP KILRKISSIA NSFLYMQKTL RQCQEQRQCH CRQEATNATR 120
  121 VIHDNYDQLE VHAAAIKSLG ELDVFLAWIN KNHEVMSSA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 47.522879
Match: 1n1fA
Description: Interleukin-19
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor binding 5.3304255990112 bayes_pls_golite062009
cytokine activity 4.52280271433847 bayes_pls_golite062009
cytokine receptor binding 3.77877275351612 bayes_pls_golite062009
growth factor activity 3.72884804690203 bayes_pls_golite062009
protein binding 3.26483713001551 bayes_pls_golite062009
binding 2.48265117231403 bayes_pls_golite062009
interleukin-10 receptor binding 2.03829634645987 bayes_pls_golite062009
hormone activity 1.36735241300603 bayes_pls_golite062009
catalytic activity 0.246169290135575 bayes_pls_golite062009
interleukin-6 receptor binding 0.0605673585279907 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle