YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|55670498
Organism:	Homo sapiens
Length:	204 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|55670498.

Description	E-value	Query Range	Subject Range
ERI1 - exoribonuclease 1 gi\|123979876, gi... - gi\|123994641\|gb\|ABM84922.1\| three prime histone mRNA exonuclease 1 [synthetic construct], gi\|1239798...	176.0	[0..2]	[203..120]
gi\|114623463 - gi\|114623463\|ref\|XP_001136735.1\| PREDICTED: histone mRNA 3' end-specific exonuclease isoform 1 [Pan ...	176.0	[0..2]	[203..120]
gi\|81673840, gi\|... - gi\|84000359\|ref\|NP_001033281.1\| three prime histone mRNA exonuclease 1 [Bos taurus], gi\|81673840\|gb\|...	175.0	[0..2]	[203..120]
gi\|66472518, gi\|... - gi\|66472518\|ref\|NP_001018450.1\| exoribonuclease 1 [Danio rerio], gi\|63100708\|gb\|AAH95343.1\| Exoribon...	175.0	[0..5]	[202..111]
gi\|73979366 - gi\|73979366\|ref\|XP_539997.2\| PREDICTED: similar to histone mRNA 3 end-specific exonuclease [Canis fa...	173.0	[0..6]	[203..124]
gi\|26379605 - gi\|26379605\|dbj\|BAB29127.2\| unnamed protein product [Mus musculus]	173.0	[0..2]	[203..116]
ERI1_RAT - 3'-5' exoribonuclease 1 OS=Rattus norvegicus GN=Eri1 PE=2 SV=1	173.0	[0..2]	[203..116]
gi\|47218345 - gi\|47218345\|emb\|CAG04177.1\| unnamed protein product [Tetraodon nigroviridis]	170.0	[0..6]	[203..115]

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Predicted Domain #1

Region A:
Residues: [1-204]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSHXADSYYD YICIIDFEAT CEEGNPPEFV HEIIEFPVVL LNTHTLEIED TFQQYVRPEI  60
   61 NTQLSDFCIS LTGITQDQVD RADTFPQVLK KVIDWXKLKE LGTKYKYSLL TDGSWDXSKF 120
  121 LNIQCQLSRL KYPPFAKKWI NIRKSYGNFY KVPRSQTKLT IXLEKLGXDY DGRPHCGLDD 180
  181 SKNIARIAVR XLQDGCELRI NEKX

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	45.045757
Match:	1w0hA
Description:	Crystallographic structure of the nuclease domain of 3'hExo, a DEDDh family member, bound to rAMP
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
nuclease activity	0.998156409183357	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	0.635128673319958	bayes_pls_golite062009
binding	0.278320556458895	bayes_pls_golite062009
protein binding	0.058257360610363	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: