YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|20664330, gi\|...
Organism:	Homo sapiens
Length:	315 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|20664330, gi|....

Description	E-value	Query Range	Subject Range
gi\|109086527 - gi\|109086527\|ref\|XP_001091897.1\| PREDICTED: similar to gamma-glutamyl hydrolase precursor [Macaca mu...	226.0	[0..11]	[315..18]
GGH - gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)	224.0	[0..11]	[315..18]
sp\|Q92820\|GGH_HU... - Gamma-glutamyl hydrolase OS=Homo sapiens GN=GGH PE=1 SV=2 VAR_014697, Gamma-glutamyl hydrolase OS=Ho... gi\|114620296, gi... - gi\|114620298\|ref\|XP_001159345.1\| PREDICTED: gamma-glutamyl hydrolase isoform 1 [Pan troglodytes], gi...	224.0	[0..11]	[315..18]
gi\|50738017 - gi\|50738017\|ref\|XP_419226.1\| PREDICTED: similar to gamma-glutamyl hydrolase precursor; conjugase; fo...	212.0	[0..11]	[315..419]
gi\|57107753 - gi\|57107753\|ref\|XP_535087.1\| PREDICTED: similar to gamma-glutamyl hydrolase precursor [Canis familia...	211.0	[0..30]	[315..33]
gi\|85712713, gi\|... - gi\|85712713\|ref\|ZP_01043758.1\| bifunctional GMP synthase/glutamine amidotransferase protein [Idiomar...	209.0	[0..39]	[289..6]
GGH_MOUSE - Gamma-glutamyl hydrolase OS=Mus musculus GN=Ggh PE=1 SV=2	208.0	[0..20]	[315..23]
GUAA_BACCR - GMP synthase [glutamine-hydrolyzing] OS=Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBR... gi\|229125762, gi... - gi\|229125762\|ref\|ZP_04254790.1\| GMP synthase, large subunit [Bacillus cereus BDRD-Cer4], gi\|22865770...	207.0	[0..35]	[289..3]
gi\|228937552, gi... - gi\|228937552\|ref\|ZP_04100193.1\| GMP synthase, large subunit [Bacillus thuringiensis serovar berliner... gi\|228860640, gi... - gi\|228898997\|ref\|ZP_04063272.1\| GMP synthase, large subunit [Bacillus thuringiensis IBL 4222], gi\|22... gi\|228977009, gi... - gi\|228977009\|ref\|ZP_04137416.1\| GMP synthase, large subunit [Bacillus thuringiensis Bt407], gi\|22878... gi\|74490054, gi\|... - gi\|75762461\|ref\|ZP_00742326.1\| GMP synthase (glutamine-hydrolyzing) [Bacillus thuringiensis serovar ... gi\|228789288, gi... - gi\|228970439\|ref\|ZP_04131093.1\| GMP synthase, large subunit [Bacillus thuringiensis serovar thuringi...	206.0	[0..35]	[289..3]

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Predicted Domain #1

Region A:
Residues: [1-315]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSSHHHHHH SSGLVPRGSH MRPHGDTAKK PIIGILMQKC RNKVMKNYGR YYIAASYVKY  60
   61 LESAGARVVP VRLDLTEKDY EILFKSINGI LFPGGSVDLR RSDYAKVAKI FYNLSIQSFD 120
  121 DGDYFPVWGT CLGFEELSLL ISGECLLTAT DTVDVAMPLN FTGGQLHSRM FQNFPTELLL 180
  181 SLAVEPLTAN FHKWSLSVKN FTMNEKLKKF FNVLTTNTDG KIEFISTMEG YKYPVYGVQW 240
  241 HPEKAPYEWK NLDGISHAPN AVKTAFYLAE FFVNEARKNN HHFKSESEEE KALIYQFSPI 300
  301 YTGNISSFQQ CYIFD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	60.045757
Match:	1l9xA
Description:	gamma-glutamyl hydrolase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ligase activity	1.70348758031146	bayes_pls_golite062009
catalytic activity	1.30391542469987	bayes_pls_golite062009
binding	0.245374211061945	bayes_pls_golite062009
anthranilate synthase activity	0.243205818526006	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: