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View Structure Prediction Details

Protein: gi|5822136
Organism: Homo sapiens
Length: 333 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|5822136.

Description E-value Query
Range
Subject
Range
gi|736764 - gi|736764|gb|AAB48379.1| neurofibromatosis 1 [Homo sapiens]
363.0 [0..1] [333..448]
gi|114668247 - gi|114668247|ref|XP_001174715.1| PREDICTED: neurofibromin isoform 1 [Pan troglodytes]
361.0 [0..1] [333..957]
NF1_RAT - Neurofibromin OS=Rattus norvegicus GN=Nf1 PE=1 SV=1
358.0 [0..1] [333..1200]
gi|56205959, gi|... - gi|56205959|emb|CAI24340.1| neurofibromatosis 1 [Mus musculus], gi|56205725|emb|CAI24835.1| neurofib...
356.0 [0..1] [333..1200]

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Predicted Domain #1
Region A:
Residues: [1-333]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ETVLADRFER LVELVTMMGD QGELPIAMAL ANVVPCSQWD ELARVLVTLF DSRHLLYQLL  60
   61 WNMFSKEVEL ADSMQTLFRG NSLASKIMTF CFKVYGATYL QKLLDPLLRI VITSSDWQHV 120
  121 SFEVDPTRLE PSESLEENQR NLLQMTEKFF HAIISSSSEF PPQLRSVCHC LYQVVSQRFP 180
  181 QNSIGAVGSA MFLRFINPAI VSPYEAGILD KKPPPIIERG LKLMSKILQS IANHVLFTKE 240
  241 EHMRPFNDFV KSNFDAARRF FLDIASDCPT SDAVNHSLSF ISDGNVLALH RLLWNNQEKI 300
  301 GQYLSSNRDH KAVGRRPFDK MATLLAYLGP PEH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 97.0
Match: 1nf1A
Description: GAP related domain of neurofibromin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
enzyme regulator activity 0.68732227880003 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 0.590837939249671 bayes_pls_golite062009
GTPase regulator activity 0.59070509814251 bayes_pls_golite062009
enzyme activator activity 0.53004209819211 bayes_pls_golite062009
GTPase activator activity 0.528693496432149 bayes_pls_golite062009
small GTPase regulator activity 0.10243777232979 bayes_pls_golite062009
Ras GTPase activator activity 0.0454578418356197 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle