YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|4558256, gi\|4...
Organism:	Homo sapiens
Length:	301 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|4558256, gi|4....

Description	E-value	Query Range	Subject Range
C1TC_PONPY - C-1-tetrahydrofolate synthase, cytoplasmic - Pongo pygmaeus (Orangutan) C1TC_PONAB - C-1-tetrahydrofolate synthase, cytoplasmic OS=Pongo abelii GN=MTHFD1 PE=2 SV=3	399.0	[0..1]	[301..1]
gi\|30048109 - gi\|30048109\|gb\|AAH50420.1\| Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetr...	398.0	[0..1]	[301..1]
gi\|114653489 - gi\|114653489\|ref\|XP_510001.2\| PREDICTED: methylenetetrahydrofolate dehydrogenase 1 isoform 3 [Pan tr...	397.0	[0..1]	[301..57]
gi\|86129512, gi\|... - gi\|86129512\|ref\|NP_001034392.1\| methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, metheny...	392.0	[0..1]	[301..1]
gi\|73964198 - gi\|73964198\|ref\|XP_537476.2\| PREDICTED: similar to C-1-tetrahydrofolate synthase, cytoplasmic (C1-TH...	392.0	[0..1]	[301..1]
C1TC_RAT - C-1-tetrahydrofolate synthase, cytoplasmic OS=Rattus norvegicus GN=Mthfd1 PE=1 SV=3	392.0	[0..1]	[301..1]

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Predicted Domain #1

Region A:
Residues: [1-301]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAPAEILNGK EISAQIRARL KNQVTQLKEQ VPGFTPRLAI LQVGNRDDSN LYINVKLKAA  60
   61 EEIGIKATHI KLPRTTTESE VMKYITSLNE DSTVHGFLVQ LPLDSENSIN TEEVINAIAP 120
  121 EKDVDGLTSI NAGRLARGDL NDCFIPCTPK GCLELIKETG VPIAGRHAVV VGRSKIVGAP 180
  181 MHDLLLWNNA TVTTCHSKTA HLDEEVNKGD ILVVATGQPE MVKGEWIKPG AIVIDCGINY 240
  241 VPDDKKPNGR KVVGDVAYDE AKERASFITP VPGGVGPMTV AMLMQSTVES AKRFLEKFKP 300
  301 G

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	109.0
Match:	1diaA
Description:	Methylenetetrahydrofolate dehydrogenase/cyclohydrolase; Tetrahydrofolate dehydrogenase/cyclohydrolase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits