YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|7243045
Organism:	Homo sapiens
Length:	651 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|7243045.

Description	E-value	Query Range	Subject Range
gi\|73950838 - gi\|73950838\|ref\|XP_852026.1\| PREDICTED: similar to F-box only protein 42 isoform 2 [Canis familiaris...	2.0E-77	[1..651]	[67..717]
FBX42_PONAB - F-box only protein 42 OS=Pongo abelii GN=FBXO42 PE=2 SV=1 FBX42_PONPY - F-box only protein 42 - Pongo pygmaeus (Orangutan)	2.0E-76	[1..651]	[67..717]
gi\|193786259 - gi\|193786259\|dbj\|BAG51542.1\| unnamed protein product [Homo sapiens] gi\|114554238, gi... - gi\|114554238\|ref\|XP_513066.2\| PREDICTED: F-box protein 42 isoform 4 [Pan troglodytes], gi\|114554236\|...	3.0E-76	[1..651]	[67..717]
gi\|168273224 - gi\|168273224\|dbj\|BAG10451.1\| F-box only protein 42 [synthetic construct] FBXO42 - F-box protein 42	7.0E-76	[1..651]	[67..717]
gi\|108997916 - gi\|108997916\|ref\|XP_001086461.1\| PREDICTED: F-box protein 42 isoform 3 [Macaca mulatta]	1.0E-74	[1..651]	[67..716]
gi\|109477619, gi... - gi\|62649946\|ref\|XP_342964.2\| PREDICTED: similar to F-box protein 42 [Rattus norvegicus], gi\|10947761...	2.0E-73	[1..651]	[67..717]
gi\|26324812 - gi\|26324812\|dbj\|BAC26160.1\| unnamed protein product [Mus musculus]	1.0E-72	[1..651]	[67..717]

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Predicted Domain #1

Region A:
Residues: [1-304]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EHKTAALVCK QWYRLIKGVA HQCYHGFMKA VQEGNIQWES RTYPYPGTPI TQRFSHSACY  60
   61 YDANQSMYVF GGCTQSSCNA AFNDLWRLDL NSKEWIRPLA SGSYPSPKAG ATLVVYKDLL 120
  121 VLFGGWTRPS PYPLHQPERF FDEIHTYSPS KNWWNCIVTT HGPPPMAGHS SCVIDDKMIV 180
  181 FGGSLGSRQM SNDVWVLDLE QWAWSKPNIS GPSPHPRGGQ SQIVIDDATI LILGGCGGPN 240
  241 ALFKDAWLLH MHSGPWAWQP LKVENEEHGA PELWCHPACR VGQCVVVFSQ APSGRAPLSP 300
  301 SLNS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	37.39794
Match:	1u6dX
Description:	Crystal structure of the Kelch domain of human Keap1
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [305-371]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RPSPISATPP ALVPETREYR SQSPVRSMDE APCVNGRWGT LRPRAQRQTP SGSREGSLSP  60
   61 ARGDGSP

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [372-651]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ILNGGSLSPG TAAVGGSSLD SPVQAISPST PSAPEGYDLK IGLSLAPRRG SLPDQKDLRL  60
   61 GSIDLNWDLK PASSSNPMDG MDNRTVGGSM RHPPEQTNGV HTPPHVASAL AGAVSPGALR 120
  121 RSLEAIKAMS SKGPSASAAL SPPLGSSPGS PGSQSLSSGE TVPIPRPGPA QGDGHSLPPI 180
  181 ARRLGHHPPQ SLNVGKPLYQ SMNCKPMQMY VLDIKDTKEK GRVKWKVFNS SSVVGPPETS 240
  241 LHTVVQGRGE LIIFGGLMDK KQNVKYYPKT NALYFVRAKR

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits