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A process by which a protein is transported to, or maintained in, a location within an organelle. Any process by which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. A process by which a protein is transported to, or maintained in, a location within the endoplasmic reticulum. The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane. Any process by which a protein is maintained in the endoplasmic reticulum and prevented from moving elsewhere. These include sequestration within the endoplasmic reticulum, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the endoplasmic reticulum. A process by which a protein is transported to, or maintained in, a location at an endoplasmic reticulum exit site.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: protein localization in endoplasmic reticulum
Acc: GO:0070972
Aspect: Biological Process
Desc: A process by which a protein is transported to, or maintained in, a location within the endoplasmic reticulum.
Synonyms:
  • protein localization in ER
  • protein localization to endoplasmic reticulum
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 193 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0070972 - protein localization in endoplasmic reticulum (interactive image map)
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