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The chemical reactions and pathways resulting in the breakdown of the mRNA transcript body that occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction. The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins. The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap or the 3'-poly(A) tail. The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells. The chemical reactions and pathways resulting in the breakdown of the nuclear-transcribed mRNA transcript body of an mRNA in which an amino-acid codon has changed to a nonsense codon; occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction. The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 3'-poly(A) tail. A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay
Acc: GO:0070478
Aspect: Biological Process
Desc: The chemical reactions and pathways resulting in the breakdown of the nuclear-transcribed mRNA transcript body of an mRNA in which an amino-acid codon has changed to a nonsense codon; occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction.
Synonyms:
  • 3'-5' nonsense-mediated decay
  • 3'-5' nonsense-mediated mRNA decay
  • nuclear-transcribed mRNA breakdown, 3'-5' exonucleolytic nonsense-mediated decay
  • nuclear-transcribed mRNA catabolism, 3'-5' exonucleolytic nonsense-mediated decay
  • 3'-5' NMD
  • nuclear-transcribed mRNA degradation, 3'-5' exonucleolytic nonsense-mediated decay
Proteins in PDR annotated with:
   This term: 7 [Search]
   Term or descendants: 7 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0070478 - nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle