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Any process that decreases the rate, frequency or extent of a series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound. Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade. A cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways. Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the BMK cascade. Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade. A cascade of protein kinase activities, culminating in the phosphorylation and activation of big MAP kinase (BMK1/ERK5), which is a type of mitogen-activated protein (MAP) kinase. Any process that modulates the frequency, rate or extent of signal transduction mediated by the BMK cascade.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of BMK cascade
Acc: GO:0070377
Aspect: Biological Process
Desc: Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the BMK cascade.
Synonyms:
  • inhibition of BMK cascade
  • negative regulation of ERK5 signaling pathway
  • down-regulation of BMK cascade
  • negative regulation of BMK signalling pathway
  • negative regulation of MAPK7 cascade
  • downregulation of BMK cascade
  • negative regulation of BMK1 cascade
  • down regulation of BMK cascade
  • negative regulation of BMK signaling pathway
  • negative regulation of ERK5 cascade
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 0


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0070377 - negative regulation of BMK cascade (interactive image map)
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