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Any process that modulates the rate, frequency or extent of a series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound. A cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways. Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade. Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. A cascade of protein kinase activities, culminating in the phosphorylation and activation of either the ERK1 or ERK2 kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases. Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: regulation of ERK1 and ERK2 cascade
Acc: GO:0070372
Aspect: Biological Process
Desc: Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
Synonyms:
  • regulation of ERK cascade
  • regulation of ERK1 cascade
  • regulation of MAPK1 cascade
  • regulation of ERK1 and ERK2 signaling pathway
  • regulation of ERK2 cascade
  • regulation of MAPK3 cascade
  • regulation of ERK1/2 cascade
  • regulation of ERK1 and ERK2 signalling pathway
Proteins in PDR annotated with:
   This term: 16 [Search]
   Term or descendants: 95 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0070372 - regulation of ERK1 and ERK2 cascade (interactive image map)
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Created and Maintained by: Michael Riffle