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A cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways. Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. A cascade of protein kinase activities, culminating in the phosphorylation and activation of either the ERK1 or ERK2 kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases. Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. A series of reactions that occur within the cell, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: ERK1 and ERK2 cascade
Acc: GO:0070371
Aspect: Biological Process
Desc: A cascade of protein kinase activities, culminating in the phosphorylation and activation of either the ERK1 or ERK2 kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases.
Synonyms:
  • ERK1 cascade
  • MAPK3 cascade
  • ERK2 cascade
  • MAPK1 cascade
  • ERK1/2 cascade
  • ERK1 and ERK2 signalling pathway
  • ERK1 and ERK2 signaling pathway
  • ERK cascade
Proteins in PDR annotated with:
   This term: 9 [Search]
   Term or descendants: 103 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0070371 - ERK1 and ERK2 cascade (interactive image map)
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