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The process during cotranslational membrane targeting wherein proteins move across a membrane. SRP and its receptor initiate the transfer of the nascent chain across the endoplasmic reticulum (ER) membrane; they then dissociate from the chain, which is transferred to a set of transmembrane proteins, collectively called the translocon. Once the nascent chain translocon complex is assembled, the elongating chain passes directly from the large ribosomal subunit into the centers of the translocon, a protein-lined channel within the membrane. The growing chain is never exposed to the cytosol and does not fold until it reaches the ER lumen. Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. The process by which proteins are moved across the peroxisomal membrane into the matrix. It is likely that the peroxisome targeting sequence receptor remains associated with cargo proteins during translocation. The directed movement of substances within a cell. The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. The process by which a protein translocates through the ER membrane posttranslationally. The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. The directed movement of proteins in a cell, from one side of a membrane to another. The import of proteins into the space between the inner and outer mitochondrial membranes. The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. Any process by which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: intracellular protein transmembrane transport
Acc: GO:0065002
Aspect: Biological Process
Desc: The directed movement of proteins in a cell, from one side of a membrane to another.
Synonyms:
  • intracellular membrane translocation of a protein
  • intracellular protein transport across a membrane
Proteins in PDR annotated with:
   This term: 7 [Search]
   Term or descendants: 126 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0065002 - intracellular protein transmembrane transport (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle