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The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The biological process whose specific outcome is the progression of the lung epithelium from an initial condition to its mature state. This process begins with the formation of lung epithelium and ends with the mature structure. The lung epithelium is the specialized epithelium that lines the inside of the lung. The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax. The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate. The process whereby a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium. The process whereby a relatively unspecialized cell acquires specialized features of an epithelial cell that contributes to the epithelium of the lung. The process whereby a relatively unspecialized cell acquires specialized features of a Clara cell. A Clara cell is an unciliated epithelial cell found in the respiratory and terminal bronchioles. The process whereby a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the lung epithelium. The process whereby a relatively unspecialized cell acquires specialized features of a Type II pneumocyte. A Type II pneumocyte is a surfactant secreting cell that contains abundant cytoplasm containing numerous lipid-rich multilamellar bodies. The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. The process whereby a relatively unspecialized cell acquires specialized features of a Type I pneumocyte. A type I pneumocyte is a flattened cell with greatly attenuated cytoplasm and a paucity of organelles. The process whereby a relatively unspecialized cell acquires specialized features of a lung goblet cell. A goblet cell is a cell of the epithelial lining that produces and secretes mucins.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: lung epithelial cell differentiation
Acc: GO:0060487
Aspect: Biological Process
Desc: The process whereby a relatively unspecialized cell acquires specialized features of an epithelial cell that contributes to the epithelium of the lung.
Synonyms:
  • pulmonary epithelial cell differentiation
Proteins in PDR annotated with:
   This term: 2 [Search]
   Term or descendants: 14 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0060487 - lung epithelial cell differentiation (interactive image map)
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