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Any process that modulates the rate, frequency, or extent of cell-substrate junction assembly. Cell-substrate junction assembly is the aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate. Any process that decreases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules. Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. Any process that modulates the frequency, rate or extent of focal adhesion formation, the establishment and maturation of focal adhesions. Any process that stops, prevents or reduces the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions. The binding of a cell to the extracellular matrix via adhesion molecules. Any process that stops, prevents or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. The aggregation and bonding together of a set of components to form a focal adhesion, a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also function as a locus of signal transduction activity. Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix. The aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate. A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. Any process that stops, prevents or reduces the rate or extent of cell adhesion to the extracellular matrix.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of focal adhesion assembly
Acc: GO:0051895
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions.
Synonyms:
  • down-regulation of focal adhesion formation
  • inhibition of focal adhesion formation
  • downregulation of focal adhesion formation
  • down regulation of focal adhesion formation
Proteins in PDR annotated with:
   This term: 14 [Search]
   Term or descendants: 14 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0051895 - negative regulation of focal adhesion assembly (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle