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Catalysis of the removal of a methyl group from a substrate. Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. Catalysis of the removal of a methyl group from one or more nucleosides within a DNA molecule. Catalysis of the reaction: methyl-dCpdG DNA + H2O = dCpdG DNA + methanol. This reaction is the hydrolytic removal of the methyl group on the 5 position of cytosine in DNA.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: cytosine C-5 DNA demethylase activity
Acc: GO:0051747
Aspect: Molecular Function
Desc: Catalysis of the reaction: methyl-dCpdG DNA + H2O = dCpdG DNA + methanol. This reaction is the hydrolytic removal of the methyl group on the 5 position of cytosine in DNA.
Synonyms:
  • DNA demethylase activity
  • DNA methyltransferase activity acting on cytosine C-5
  • hydrolytic DNA demethylase activity
Proteins in PDR annotated with:
   This term: 8 [Search]
   Term or descendants: 8 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0051747 - cytosine C-5 DNA demethylase activity (interactive image map)
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