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Any process that modulates the frequency, rate or extent of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate. Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds. Any process that stops or reduces the rate of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate. Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. Any process that stops or reduces the activity of an enzyme.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of cyclic-nucleotide phosphodiesterase activity
Acc: GO:0051344
Aspect: Biological Process
Desc: Any process that stops or reduces the rate of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate.
Synonyms:
  • cAMP phosphodiesterase inhibitor
  • negative regulation of cyclic nucleotide phosphodiesterase activity
  • down regulation of cyclic nucleotide phosphodiesterase activity
  • negative regulation of 3',5'-cyclic-AMP phosphodiesterase activity
  • downregulation of cyclic nucleotide phosphodiesterase activity
  • 3',5'-cyclic-AMP phosphodiesterase inhibitor
  • 3',5' cyclic nucleotide phosphodiesterase inhibitor
  • negative regulation of 3',5' cyclic nucleotide phosphodiesterase activity
  • negative regulation of cGMP phosphodiesterase activity
  • phosphodiesterase inhibitor
  • down-regulation of cyclic nucleotide phosphodiesterase activity
  • inhibition of cyclic nucleotide phosphodiesterase activity
  • negative regulation of cAMP phosphodiesterase activity
Proteins in PDR annotated with:
   This term: 2 [Search]
   Term or descendants: 2 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0051344 - negative regulation of cyclic-nucleotide phosphodiesterase activity (interactive image map)
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