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Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances. Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. The chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase, which catalyzes the reaction: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase. Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase. Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: negative regulation of thymidylate synthase biosynthetic process
Acc: GO:0050760
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase.
Synonyms:
  • negative regulation of thymidylate synthase anabolism
  • negative regulation of thymidylate synthase formation
  • down regulation of thymidylate synthase biosynthetic process
  • down-regulation of thymidylate synthase biosynthetic process
  • negative regulation of thymidylate synthase biosynthesis
  • inhibition of thymidylate synthase biosynthetic process
  • downregulation of thymidylate synthase biosynthetic process
  • negative regulation of thymidylate synthase synthesis
Proteins in PDR annotated with:
   This term: 1 [Search]
   Term or descendants: 1 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0050760 - negative regulation of thymidylate synthase biosynthetic process (interactive image map)

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