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Catalysis of the reaction: phosphoenolpyruvate + N-acetyl-D-mannosamine + H2O = phosphate + N-acetylneuraminate . Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: N-acetylneuraminate synthase activity
Acc: GO:0050462
Aspect: Molecular Function
Desc: Catalysis of the reaction: phosphoenolpyruvate + N-acetyl-D-mannosamine + H2O = phosphate + N-acetylneuraminate .
Synonyms:
  • N-acetylneuraminate pyruvate-lyase (pyruvate-phosphorylating) activity
  • NeuAc synthase activity
  • (NANA)condensing enzyme activity
  • N-acetylneuraminic acid synthase activity
  • phosphoenolpyruvate:N-acetyl-D-mannosamine C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 0


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0050462 - N-acetylneuraminate synthase activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle