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Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears. Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate. Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: prostaglandin-E synthase activity
Acc: GO:0050220
Aspect: Molecular Function
Desc: Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate.
Synonyms:
  • prostaglandin-H2 E-isomerase activity
  • prostaglandin endoperoxide E2 isomerase activity
  • prostaglandin R-prostaglandin E isomerase activity
  • endoperoxide isomerase activity
  • prostaglandin endoperoxide E isomerase activity
  • prostaglandin H-E isomerase activity
  • Prostaglandin-H(2) E-isomerase activity
  • PGE isomerase activity
  • (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase activity
  • PGE2 isomerase activity
  • PGH-PGE isomerase activity
Proteins in PDR annotated with:
   This term: 6 [Search]
   Term or descendants: 6 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0050220 - prostaglandin-E synthase activity (interactive image map)
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