YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

A complex consisting of a protein and RNA component which binds the signal sequence of some proteins and facilitates their export to the chloroplast. A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana. Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. A complex consisting of a protein and RNA component which binds the signal sequence of some proteins and facilitates their export to or across the plasma membrane. A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together. A macromolecular complex containing both protein and RNA molecules. A complex of protein and RNA which facilitates translocation of proteins across membranes. Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: signal recognition particle
Acc: GO:0048500
Aspect: Cellular Component
Desc: A complex of protein and RNA which facilitates translocation of proteins across membranes.
Proteins in PDR annotated with:
   This term: 23 [Search]
   Term or descendants: 86 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0048500 - signal recognition particle (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle