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Catalysis of the reactions: (1) 5beta-cholestan-3-one + NADP+ = cholest-4-en-3-one + NADPH + H+ and (2) 17,21-dihydroxy-5beta-pregnane-3,11,20-trione + NADP+ = cortisone + NADPH + H+. Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP. Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: delta4-3-oxosteroid 5beta-reductase activity
Acc: GO:0047787
Aspect: Molecular Function
Desc: Catalysis of the reactions: (1) 5beta-cholestan-3-one + NADP+ = cholest-4-en-3-one + NADPH + H+ and (2) 17,21-dihydroxy-5beta-pregnane-3,11,20-trione + NADP+ = cortisone + NADPH + H+.
Synonyms:
  • 3-oxo-Delta(4)-steroid 5-beta-reductase activity
  • androstenedione 5beta-reductase activity
  • cortisone delta(4)-5-beta-reductase activity
  • steroid 5-beta-reductase activity
  • delta(4)-hydrogenase activity
  • delta(4)-5-beta-reductase activity
  • steroid 5beta-reductase activity
  • delta4-5beta-reductase activity
  • 3-oxo-5beta-steroid:NADP+ delta4-oxidoreductase activity
  • 3-oxo-delta4-steroid 5beta-reductase activity
  • GO:0047752
  • testosterone 5beta-reductase activity
  • cholestenone 5b-reductase activity
  • delta(4)-3-ketosteroid 5-beta-reductase activity
  • delta4-hydrogenase activity
  • delta4-3-ketosteroid 5beta-reductase activity
  • 5beta-reductase activity
  • cortisone delta4-5beta-reductase activity
  • delta-4-3-oxosteroid 5-beta-reductase activity
  • 4,5beta-dihydrocortisone:NADP+ delta4-oxidoreductase activity
  • 5beta-cholestan-3-one:NADP+ 4,5-oxidoreductase activity
  • androstenedione 5-beta-reductase activity
  • cholestenone 5-beta-reductase activity
  • 5-beta-reductase activity
  • cortisone 5-beta-reductase activity
  • cortisone 5beta-reductase activity
  • testosterone 5-beta-reductase activity
  • cortisone beta-reductase activity
  • cholestenone 5beta-reductase activity
  • cortisone b-reductase activity
Proteins in PDR annotated with:
   This term: 1 [Search]
   Term or descendants: 1 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0047787 - delta4-3-oxosteroid 5beta-reductase activity (interactive image map)
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Created and Maintained by: Michael Riffle