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Catalysis of the formation of sialylglycoconjugates via transfer of the sialic acid group from CMP to one of several glycoconjugate acceptors. Catalysis of the reaction: cytolipin-H + CMP-N-acetylneuraminate = alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + CMP. Alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide is also known as GM3. Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: lactosylceramide alpha-2,3-sialyltransferase activity
Acc: GO:0047291
Aspect: Molecular Function
Desc: Catalysis of the reaction: cytolipin-H + CMP-N-acetylneuraminate = alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + CMP. Alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide is also known as GM3.
Synonyms:
  • GM3 synthetase activity
  • cytidine monophosphoacetylneuraminate-lactosylceramide sialyltransferase
  • CMP-acetylneuraminate-lactosylceramide-sialyltransferase
  • ganglioside GM3 synthase activity
  • SAT 1
  • CMP-N-acetylneuraminate:lactosylceramide alpha-2,3-N-acetylneuraminyltransferase activity
  • cytidine monophosphoacetylneuraminate-lactosylceramide alpha2,3- sialyltransferase activity
  • CMP-sialic acid:lactosylceramide-sialyltransferase activity
  • GM3 synthase activity
  • CMP-acetylneuraminic acid:lactosylceramide sialyltransferase activity
  • ganglioside GM3 synthetase activity
Proteins in PDR annotated with:
   This term: 4 [Search]
   Term or descendants: 4 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0047291 - lactosylceramide alpha-2,3-sialyltransferase activity (interactive image map)
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Created and Maintained by: Michael Riffle