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Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP, and in which one substrate is a sterol derivative. Catalysis of the reaction: NADP+ + 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate = NADPH + H+ + 3-alpha,7-alpha-dihydroxy-12-oxo-5-beta-cholanate. Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative. Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: 12-alpha-hydroxysteroid dehydrogenase activity
Acc: GO:0047013
Aspect: Molecular Function
Desc: Catalysis of the reaction: NADP+ + 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate = NADPH + H+ + 3-alpha,7-alpha-dihydroxy-12-oxo-5-beta-cholanate.
Synonyms:
  • NAD-dependent 12alpha-hydroxysteroid dehydrogenase activity
  • NADP-12alpha-hydroxysteroid dehydrogenase activity
  • 12alpha-hydroxysteroid:NADP+ 12-oxidoreductase activity
  • 12alpha-hydroxy steroid dehydrogenase activity
  • 12alpha-hydroxysteroid dehydrogenase activity
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 0


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0047013 - 12-alpha-hydroxysteroid dehydrogenase activity (interactive image map)
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