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The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. The chemical reactions and pathways resulting in the formation of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Biosynthesis involves the formation of hydroxymethylglutaryl-CoA, which is cleaved to acetate and acetyl-CoA. The chemical reactions and pathways involving ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone, as carried out by individual cells. Although 3-hydroxybutyrate is not a ketone, it is classed as a ketone body because it exists in an equilibrium with acetoacetate. Ketone bodies may accumulate in excessive amounts in the body in starvation, diabetes mellitus or in other defects of carbohydrate metabolism. The chemical reactions and pathways resulting in the formation of small molecules, any monomeric molecule of small relative molecular mass. The chemical reactions and pathways involving small molecules, any monomeric molecule of small relative molecular mass. The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. The chemical reactions and pathways by which individual cells transform chemical substances.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: ketone body biosynthetic process
Acc: GO:0046951
Aspect: Biological Process
Desc: The chemical reactions and pathways resulting in the formation of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Biosynthesis involves the formation of hydroxymethylglutaryl-CoA, which is cleaved to acetate and acetyl-CoA.
Synonyms:
  • ketone body synthesis
  • ketone body anabolism
  • ketone body formation
  • ketone body biosynthesis
Proteins in PDR annotated with:
   This term: 4 [Search]
   Term or descendants: 4 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0046951 - ketone body biosynthetic process (interactive image map)

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