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Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or group of cells. Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. The process whereby a signal is secreted or discharged into the extracellular medium from a cellular source. Any process that stops, prevents or reduces the frequency, rate or extent of the controlled release of a substance from a cell or group of cells. Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell or group of cells. Any process that modulates the frequency or rate of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of a neurotransmitter. The controlled release of a substance by a cell, a group of cells, or a tissue. The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin. Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of acetylcholine. Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into, out of, within or between cells by means of some external agent such as a transporter or pore. Any process that modulates levels of neurotransmitter. Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. The directed movement of a neurotransmitter into, out of, within or between cells by means of some external agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into, out of, within or between cells by means of some external agent such as a transporter or pore. The controlled release of a substance by a cell. Any process that modulates the frequency, rate or extent of a process by which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell. Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells by means of some external agent such as a transporter or pore.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of neurotransmitter secretion
Acc: GO:0046929
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of a neurotransmitter.
Synonyms:
  • down-regulation of neurotransmitter secretion
  • down regulation of neurotransmitter secretion
  • downregulation of neurotransmitter secretion
  • conotoxin activity
  • inhibition of neurotransmitter secretion
Proteins in PDR annotated with:
   This term: 2 [Search]
   Term or descendants: 4 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0046929 - negative regulation of neurotransmitter secretion (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle