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The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction. A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor. Any process that activates or increases the frequency, rate or extent of lymphocyte activation. Any process that modulates the frequency, rate or extent of lymphocyte activation. The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor. The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor. The process whereby a relatively unspecialized precursor cell acquires specialized features of B cells, T cells, or natural killer cells. A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte activation. The expansion of a lymphocyte population by cell division. The directed orientation of lymphocyte signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with an appropriate activating cell. A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand. Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: lymphocyte activation
Acc: GO:0046649
Aspect: Biological Process
Desc: A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor.
Proteins in PDR annotated with:
   This term: 4 [Search]
   Term or descendants: 538 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0046649 - lymphocyte activation (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle