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A process whereby force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length. Any process that modulates the frequency, rate or extent of muscle contraction. Any process that stops, prevents or reduces the frequency, rate or extent of muscle contraction. A process whereby force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Any process that decreases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine. Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle contraction. Any process that stops, prevents or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. Any process that modulates the frequency, rate or extent of uterine smooth muscle contraction. Any process that modulates the frequency, rate or extent of smooth muscle contraction. A process whereby the extent of smooth muscle contraction is reduced in the bladder outlet that contributes to the expulsion of urine from the body. A process whereby the extent of vascular smooth muscle contraction is reduced. Vascular smooth muscle relaxation is mediated via a decrease in the phosphorylation state of myosin light chain. This can be achieved by removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases leading to a decrease myosin light chain kinase activity, and through calcium-independent pathways leading to a increase in myosin light chain phosphatase activity.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of smooth muscle contraction
Acc: GO:0045986
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle contraction.
Synonyms:
  • smooth muscle relaxation
  • inhibition of smooth muscle contraction
  • down regulation of smooth muscle contraction
  • down-regulation of smooth muscle contraction
  • downregulation of smooth muscle contraction
Proteins in PDR annotated with:
   This term: 15 [Search]
   Term or descendants: 30 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0045986 - negative regulation of smooth muscle contraction (interactive image map)
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