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Any process that modulates the frequency, rate or extent of complement activation. Any process that modulates the frequency, rate or extent of the alternative pathway of complement activation. Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process. Any process that stops, prevents or reduces the frequency, rate or extent of complement activation. Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes. Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway. Any process that stops, prevents or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. Any process that stops, prevents or reduces the frequency, rate or extent of a defense response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection. Any process that stops, prevents or reduces the frequency, rate or extent of complement activation by the alternative pathway. Any process that decreases the rate, frequency or extent of protein maturation by peptide bond cleavage. Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response. Any process that stops, prevents or reduces the frequency, rate or extent of the innate immune response.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of complement activation, alternative pathway
Acc: GO:0045957
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of complement activation by the alternative pathway.
Synonyms:
  • down regulation of complement activation, alternative pathway
  • downregulation of complement activation, alternative pathway
  • inhibition of complement activation, alternative pathway
  • down-regulation of complement activation, alternative pathway
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 0


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0045957 - negative regulation of complement activation, alternative pathway (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle