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Any process that stops, prevents, or reduces the rate of complement activation by the lectin pathway. Any process that modulates the frequency, rate or extent of complement activation. Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process. Any process that modulates the frequency, rate, or extent of an acute inflammatory response. Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process. Any process that modulates the frequency, rate, or extent of an immune effector process. Any process that stops, prevents or reduces the frequency, rate or extent of complement activation. The hydrolysis of a peptide bond or bonds within a protein as part of protein maturation, the process leading to the attainment of the full functional capacity of a protein. Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway. Any process that modulates the rate, frequency or extent of protein maturation by peptide bond cleavage. Any process of the immune system that occurs as part of an immune response. Any process that stops, prevents or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. Any process that initiates an immune response. Any process that stops, prevents or reduces the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade. An immune response mediated through a body fluid. Any process activating plasma proteins by proteolysis as part of an acute inflammatory response. Any process that stops, prevents or reduces the frequency, rate or extent of complement activation by the classical pathway. Any process that modulates the frequency, rate, or extent of a humoral immune response. Any process that stops, prevents or reduces the frequency, rate or extent of complement activation by the alternative pathway. Any process that decreases the rate, frequency or extent of protein maturation by peptide bond cleavage. Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of complement activation
Acc: GO:0045916
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of complement activation.
Synonyms:
  • down-regulation of complement activation
  • inhibition of complement activation
  • down regulation of complement activation
  • downregulation of complement activation
Proteins in PDR annotated with:
   This term: 18 [Search]
   Term or descendants: 25 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0045916 - negative regulation of complement activation (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle